Sodium, salt of tris

Thus, [HRh(C0)(TPPTS)3]/H20/silica (TPPTS = sodium salt of tri(m-sulfophenyl)phopshine) catalyzes the hydroformylation of heavy and functionalized olefins,118-122 the selective hydrogenation of a,/3-unsaturated aldehydes,84 and the asymmetric hydrogenation of 2-(6 -methoxy-2 -naphthyl)acrylic add (a precursor of naproxen).123,124 More recently, this methodology was tested for the palladium-catalyzed Trost Tsuji (allylic substitution) and Heck (olefin arylation) reactions.125-127... 

In a 100-mL Schlenk tube equipped with a magnetic stirrer, 1.95 equiv (4.83 g) of the sodium salt of tris(3-sulfonatophenyl)phosphine (TPPTS) dissolved in a minimum amount of water (ca. 5 mL) are added at room temperature to the solution of [NH2Me2] [Rh(CO)2Cl2] prepared as described in Section 21.K. The reaction is fast, with significant CO evolution. After 15 min, an IR spectmm of the solution shows a single vco band at 1982 cm. The yellow product is precipitated by adding 50 mL of cold ethanol, then collected by filtration on a Buchner funnel, washed with 150 mL of ethanol, and dried under vacuum. Yield 3.81 g (71%). 

A-(phosphonomethyl) glycine is obtained in a good yield by reacting the sodium salt of tris-(carboxymethyl)-hexahydro-5-triazine with phosphonic acid diesters [83]. 

The reaction is particularly facile with di- and tri-hydric phenols. Thus P-resorcyllc acid is readily obtained by passing carbon dioxide through a boiling aqueous solution of the potassium or sodium salt of resorcinol ... 

Figure 2 Stability of /3-poly(L-malate) measured by its activity to inhibit purified DNA polymerase a of P. polyceph-alum. The relative degree of inhibition is shown (100 rel. units refer to complete inhibition). The DNA polymerase assay was carried out in the presence of 5 /tg/ml /S-poly(L-malate) as described [4]. The polymer was preincubated for 7 days at 4°C in the following buffer solutions (50 mM) KCl/HCl (—A—). Citrate (—V—). 2-(A/-Morpholino)-ethanesulfonic acid, sodium salt (—O—). Sodium phosphate (— —). N-(2-Hydroxyethyl)piperazine-N -(2-ethanesul-fonic acid), sodium salt (— — ). N,N-b s (2-Hydroxyethyl)-glycine, sodium salt (—T—). Tris/HCl (— —). 3-(Cyclo-hexylamino)-l-propanesulfonic acid, sodium salt (— —).

A. Nucleophilic Reactions of the P=0 Group.—Tris(trifluoromethyl)-phosphine oxide (33) reacts with hexamethyldisiloxane to give a phos-phorane, whose n.m.r. spectrum at — 140 °C shows non-equivalent trifluoromethyl groups. Although this unusual reaction clearly involves nucleophilic attack of the phosphoryl oxygen on silicon at some stage of the reaction, a full study of the mechanism has not been published. Tertiary phosphine oxides can be converted cleanly into dichlorophos-phoranes (34) by treatment with two moles of phosphorus pentachloride. Alkylation of the sodium salt of tetraphenylmethylenediphosphine dioxide (35) with alkyl halides, in dimethyl sulphoxide, has been reported to... 

The reactions of the sodium salt of diethyl malonate and 4-(triisopropyl-phenylsulfonyloxide) derivatives of tris-(fe/7-butyldimethylsilyl)uridine (487, R = H) and di-(rm-butyldimethylsilyl)thymidine (487, R = Me) in THF at 0°C afforded the corresponding diethyl 4-pyrimidinylidenemalo-nates (488) in 88-89% yields (87TL2821). 

Marchand and co-workers reported a synthetic route to TNAZ (18) involving a novel electrophilic addition of NO+ NO2 across the highly strained C(3)-N bond of 3-(bromomethyl)-l-azabicyclo[1.1.0]butane (21), the latter prepared as a nonisolatable intermediate from the reaction of the bromide salt of tris(bromomethyl)methylamine (20) with aqueous sodium hydroxide under reduced pressure. The product of this reaction, A-nitroso-3-bromomethyl-3-nitroazetidine (22), is formed in 10% yield but is also accompanied by A-nitroso-3-bromomethyl-3-hydroxyazetidine as a by-product. Isolation of (22) from this mixture, followed by treatment with a solution of nitric acid in trifluoroacetic anhydride, leads to nitrolysis of the ferf-butyl group and yields (23). Treatment of (23) with sodium bicarbonate and sodium iodide in DMSO leads to hydrolysis of the bromomethyl group and the formation of (24). The synthesis of TNAZ (18) is completed by deformylation of (24), followed by oxidative nitration, both processes achieved in one pot with an alkaline solution of sodium nitrite, potassium ferricyanide and sodium persulfate. This route to TNAZ gives a low overall yield and is not suitable for large scale manufacture. 

Sufficient tri-n-butyl phosphate (TBP) or isodecanol is incorporated into the organic phase to prevent separation of the sodium salt of D2EHPA as a third phase. Uranium is precipitated from the strip solution by the addition of magnesium oxide or ammonia gas to give a product known as yellow cake . 

When l-(2,4-dinitrophenyl)pyrazole is heated with aqueous alkali, the C—N link is cleaved by a nucleophilic displacement with the formation of pyrazole and the sodium salt of 2,4-dinitrophenol.718 The carbon-nitrogen link is also cleaved readily when more than one pyrazolyl group is joined via nitrogen to the same carbon atom. Thus tri-l-pyrazolylmethane (78) on heating with aqueous acetic acid decomposes to pyrazole and 1-formylpyrazole.719... 

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