Sodium L -tartrate

Figure 5.45 Cationic gemini amphiphiles having chiral counterions. TEM images of representative twisted ribbons formed by 16-2-16 tartrate (49 + 50) at 0.1% in water for various values of enantiomeric excess (a) 0 (racemate) (b) 0.5 (c) 1 (pure L) (d) 1 (pure L) in presence of 1 eq sodium L-tartrate. Bar = 100 nm. Reprinted with permission from Ref. 165. Copyright 1999 by Macmillan Magazines.

DISODIUM l-(+)-TARTRATE SODIUM TARTRATE (FCC) SODIUM l-(+)-TARTRATE... 

Synonyms 2,3-Dihydroxybutanedioic acid, monopotassium monosodium salt Monopotassium monosodium tartrate Potassium sodium L-(+)-tartrate Potassium sodium tartrate anhydrous Rochelle salt Seignette salt Sodium potassium tartrate Classification Organic salt Definition Sodium potassium salt of L-tartaric acid avail, as the tetrahydrate Empirical C4H4KNaOe Formula KNaC4H40e... 

Potassium sodium L-(+)-tartrate Potassium sodium tartrate anhydrous. See Potassium sodium tartrate... 

L. Pasteur (aged 26) began work on optically active sodium ammonium tartrate. 

Adrenaline Noradrenaline Dissolve 5.0 mg in 1 ml of a 0.5% w/v soln. of tartaric acid and 4 ml of buffer soln. pH 9.6, mix, add 1 ml freshly prepared 0.5% w/v soln. of sodium l,2-naphthaquinone-4-sulphonate, mix and allow to stand for 30 mts. Add 0.2 ml of a 1.0% v/v soln. of benzalkoniumchloride soln., mix, add 15 ml of toluene previously washed with buffer soln. pH 9.6 and filtered through a dry filter paper, shake for 30 mts. and allow to separate, centrifuging if necessary. Any red or purple colour in the toluene layer is not darker than that produced by treating a soln. of 0.40 mg of noradrenaline and tartrate and 9 mg of noradrenaline free adrenanline acid tartate in 1 ml of DW in a similar manner. 

Mechanical Separation of Crystals. The first instance of resolution was by L. Pasteur who was able to resolve crystals of sodium ammonium tartrate (which recrystallizes in two distinct, nonsuperimposable forms below 2TC). Although this procedure is rarely used, one might be able to seed a racemic solution resulting in only one... 

D. Tris[(2-peiiluorohexyl)ethyl]tin hydride (Note 7). A 1-L, three-necked flask and a stirring bar are dried in an oven. The fluorous tin bromide (13.8 g, 11.1 mmol) is dissolved in dry ether (275 mL) and transferred to the dried three-necked flask equipped with a thermometer, stirring bar, and an outlet to argon. The solution is cooled to O C. AIM solution of iithium aluminum hydride (LAH) in ether (11.1 mL, 11.1 mmol) is added dropwise over 45 min to the solution. The addition rate is adjusted to maintain a temperature between 0° and 1°C. The reaction mixture is stirred for 6 hr at 0°C. Water (75 mL) is slowly added (initially dropwise) with stirring to the ice-cold mixture. Sodium potassium tartrate (20%) (250 mL) is added and the mixture is transferred to a 1-L separatory funnel. The ethereal layer is separated and the aqueous layer is extracted three times with ether (3 x 100 mL). The combined extracts are dried with magnesium sulfate and vacuum filtered into a 1-L, round-bottomed flask. The solvent is evaporated under reduced pressure. The cmde product is distilled under a reduced pressure of 0.02 mm at 133-140°C to provide 11.3 g (9.69 mmol, 87%) of the pure product as an oil (Notes 8 and 9). 

Sodium Potassium Tartrate occurs as colorless crystals or as a white, crystalline powder. As it effloresces slightly in warm, dry air, the crystals are often coated with a white powder. It is a salt of L(+)-tartaric acid. One gram dissolves in 1 mL of water. It is practically insoluble in alcohol. 

SYNS ANTIMONY SODIUM OXIDE-l-(+)-TARTRATE NATRIUMANTLMONYLTARTRAT (GERMAN) SODIUM ANTIMONYL TARTRATE SODIUM ANTIMONY TARTRATE STIBNAL STIBUNAL... 

Racemic acetylacetonatobis(ethylenediamine)cobalt(III) ion was first prepared by Werner and Matissen from the hydroxoaquo complex. Later Werner, Schwyzer, and Kar-rer prepared the optical antipodes from the resolved chloro-aquobis(ethylenediamine)cobalt(III) cation. The present method describes an efficient preparation and a simple resolution of the racemic salt using sodium (-l-)-arsenyl tartrate as the resolving agent. 

The resultant light yellow solution is stirred at -78°C for 12 hr (Note 6). During this time, the color of the solution intensifies considerably. The bright yellow solution is warmed to 0°C in an ice water bath and stirred for 35 min, during which time the color of the solution becomes bright yellow-orange. The reaction is then quenched by the sequential addition of 270 mL of saturated aqueous ammonium chloride and 200 mL of saturated aqueous sodium potassium tartrate. The emulsion is removed from the ice water bath and stirred vigorously for 50 min, by which time adequate phase separation is observed (Note 7). The biphasic mixture is transferred to a 2-L separatory funnel and is extracted with four 175-mL portions of dichloromethane. The combined extracts are washed sequentially with two 500-mL portions of an ice-cooled IM aqueous solution of sodium bisulfate, three 500-mL portions of saturated aqueous sodium bicarbonate and 500 mL of saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate, filtered, and is concentrated under reduced pressure to afford 8.5 g of a yellow oil. 

In 1951, it became possible to determine whether Rosanoff s guess was right. Ordinary X-ray crystallography cannot distinguish between a d and a l isomer, but by use of a special technique, Bijvoet was able to examine sodium rubidium tartrate and found that Rosanoff had made the correct choice. It was perhaps historically fitting that the first true absolute configuration should have been determined on a salt of tartaric acid, since Pasteur made his great discoveries on another salt of this acid. 

Table 2 shows the extent of inhibition effected by various substances on the activity of the three isoenzymes. Assays were carried out in 0.05 M sodium citrate, pH 4.9, at 37°C. The concentration of substrate was 0.0055M p-nitrophenyl phosphate the reaction was allowed to proceed for 15 minutes, then was stopped by the addition of sodium hydroxide. Units were expressed as micromoles of substrate hydrolyzed per minute per milliliter of enzyme solution. It may be seen that p-choromercuribenzoate completely inhibited isoenzyme III, while affecting isoenzymes I and II only slightly. The inhibitions by l- (+) -tartrate and fluoride were in the reverse directions. 

Acetic acid (2 mL) was added to a stirred suspension of tetramethylanunonium triace-toxyborohydride (1.54 g, 5.85 nunol) in acetonitrile (2 mL) at room temperature. The mixture was stirred at room temperature for 30 min and then cooled to -40 °C. The P-hydroxyketone (300 mg, 0.731 mmol) in acetonitrile (2 mL) was added dropwise at this temperature. A solution of camphorsulfonic acid (85 mg, 0.366 mmol) in a mixture of acetic acid acetonitrile (1 1,4 mL) was added, and the mixture was allowed to warm to -22 °C over 18 h. The mixture was poured into saturated aqueous NaHCOs (50 mL). A saturated aqueous solution of sodium potassium tartrate (50 mL) was added, followed by ether (100 mL), and the mixture was stirred vigorously at room temperature for 8 h. The layers were separated, and the aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic extracts were washed with water (50 mL), brine (50 mL), and dried (MgSO4). The solvent was removed under vacuum to afford 300 mg (99.5%, dr >97 3) of the anz/-l,3-diol as a colorless oil. 

Tables IV-VIII describe the Pfeiffer Effect on the D.L-fNi(o-phen)o] with ( +) -tartaric acid, sodium hydrogen (+) tartrate, the diethyl-2-methoxy-...

A solution of 20 mg of this complex in 20 mL of water is charged on a column containing SP-Sephadex C-25 (2.5 cm x 110 cm, Na+ form). When the elution is carried out with 0.05 mole/L sodium antimonyl-( + )-tartrate, two bands descend. When the earlier band has descended to four fifths of the column height,... 

---