SOAP approach

While the SOAP approach is very practical and systematic, it may not be appropriate for many pharmacists because there are limitations with respect to consistent access to certain data elements available in many practice settings. Additional concerns relate to the redundancy created in a patient record if the pharmacy documentation is to become part of an existing record. Such patient medical records are already voluminous, and only succinct, essential information needs to be added. Thus the contributions of pharmacist-generated documentation should be supportive of a patient s care plan to assist in achieving defined therapeutic objectives and/or avoiding drug-related problems (DRPs) where appropriate."... 

One may rationalize emulsion type in terms of interfacial tensions. Bancroft [20] and later Clowes [21] proposed that the interfacial film of emulsion-stabilizing surfactant be regarded as duplex in nature, so that an inner and an outer interfacial tension could be discussed. On this basis, the type of emulsion formed (W/O vs. O/W) should be such that the inner surface is the one of higher surface tension. Thus sodium and other alkali metal soaps tend to stabilize O/W emulsions, and the explanation would be that, being more water- than oil-soluble, the film-water interfacial tension should be lower than the film-oil one. Conversely, with the relatively more oil-soluble metal soaps, the reverse should be true, and they should stabilize W/O emulsions, as in fact they do. An alternative statement, known as Bancroft s rule, is that the external phase will be that in which the emulsifying agent is the more soluble [20]. A related approach is discussed in Section XIV-5. 

Commercially, soap is most commonly produced through either the direct saponification of fats and oils with caustic or the hydrolysis of fats and oils to fatty acids followed by stoichiometric (equal molar) neutralization with caustic. Both of these approaches yield workable soap in the form of concentrated soap solutions (- 70% soap). This concentration of soap is the target on account of the aqueous-phase properties of soap as well as practical limitations resulting from these properties. Hence, before discussing the commercial manufacturing of soap, it is imperative to understand the phase properties of soap. 

Fatty Acid Neutralization. Another approach to produce soap is through the neutralization of fatty acids with caustic. This approach requires a stepwise process where fatty acids are produced through the hydrolysis of fats and oils by water, followed by subsequent neutralization with appropriate caustics. This approach has a number of inherent benefits over the saponification process. 

Traditionally, this process has been utilized primarily for simple soap bars because it tends to be time-consuming and thus somewhat limited for large-scale bar production. However, advances have been reported in automating this approach (14). Furthermore, the process requires fluid cmtcher compositions for flow into the molds. This typically requires the formulation to contain either a high level of solvents, including water, glycerol, and alcohol, and be at elevated temperatures (>80° C) when poured into the frames. Despite these limitations, it has proven to be the preferred route to producing certain specialty products, for example, transparent bars. 

These surfactants, in conjunction with soap, produce bars that may possess superior lathering and rinsing in hard water, greater lather stabiUty, and improved skin effects. Beauty and skin care bars are becoming very complex formulations. A review of the Hterature clearly demonstrates the complexity of these very mild formulations, where it is not uncommon to find a mixture of synthetic surfactants, each of which is specifically added to modify various properties of the product. Eor example, one approach commonly reported is to blend a low level of soap (for product firmness), a mild primary surfactant (such as sodium cocoyl isethionate), a high lathering or lather-boosting cosurfactant, eg, cocamidopropyl betaine or AGS, and potentially an emollient like stearic acid (27). Such benefits come at a cost to the consumer because these materials are considerably more expensive than simple soaps. 

Staphylococcus aureus is responsible for a variety of skin infections which require therapeutic approaches different from those of streptococcal infections. Staphylococcal celluhtis is indistinguishable clinically from streptococcal cellulitis and responds to cloxacillin or flucloxacillin, but generally fails to respond to penicillin owing to penicillinase (/3-lactamase) production. Staphylococcus aureus is an important cause of superficial, localized skin sepsis which varies ftom small pustules to boils and occasionally to a more deeply invasive, suppurative skin abscess known as a carbuncle. Antibiotics are generally not indicated for these conditions. Pustules and boils settle with antiseptic soaps or creams and often discharge spontaneously, whereas carbuncles frequently require surgical drainage. Staphylococcus aureus may also cause... 

In principle, the iterative experimental approach one would take today is no different than the one pursued by the product developers at Lever Brothers Co. in the early 1950 s, though possibly accumulated data about surfactants, fatty acids, and soaps in the public domain might make ingredient selection some-... 

The thermodynamics of thin liquid films and adhesion is well documented in the literature [15,17,100-103]. The first theoretical approaches were developed mainly for thin soap films. Most of the results of the thermodynamics of soap... 

Therefore, the stability and lifetime of such thin films will be dependent on these different characteristics. This is evident from the fact that, as an air bubble is blown under the surface of a soap or detergent solution, it will rise up to the surface. It may remain at the surface if the speed is slow, or it may escape into the air as a soap bubble. Experiments show that a soap bubble consists of a very thin liquid him with an iridescent surface. But, as the huid drains away and the thickness decreases, the bubble approaches the equivalent of barely two surfactant molecules plus a few molecules of water. It is worth noting that the limiting thickness is of the order of two or more surfactant molecules. This means that one can see with the naked eye the molecular-size structures of thin liquid hlms (TLFs) (if curved). 

The product of hydrolysis is naturally an acid soap of varying composition. In any dilute solutions of sodium palmitate it approaches that of the sodium hydrogen soap NaHTg. McBain and Taylor found that the acid soap at 90 0. had the composition HP.2NaP. 

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