SMEDDS system

Cui, S., Zhao, C., Chen, D., He, Z. (2005). Self-microemulsilying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria lobata isoflavone. Drug Development and Industrial Pharmacy, 31, 349-356. 

Holm, R., Porter, C.J.H., Edwards, GA., Mullertz, A., Kristensen, H.G, and Charman, W.N. (2003) Examination of oral absorption and lymphatic transport of halofantrine in a tripie-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.Eur. J. Pharm. Sci., 20 91-97. 

The most recent development (in terms of physicochemical/particle size approaches) in the design of lipid-based delivery systems has been the use of microemulsions, microemulsion preconcentrates, or self-microemulsifying drug delivery systems (SMEDDS), typified by the Sandimmun Neoral formulation. 

Kang BK, Lee JS, Chon SK, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 2004 274 65-73. 

Table 2 Bioavailability Parameters Obtained in Male Beagle Dogs (mean SD, n = 3) After Oral Administration of 50 mg of Hf Base Formulated as Either a Long chain Self-microemulsifying Formulation (SMEDDS) or a Medium-chain Self-emulsifying (SEDDS), or Self-microemulsifying Drug Delivery System (SMEDDS)...

Shen, H.R. and Zhong, M.K. (2006) Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. /. Pharm. Pharmacol., 58, 1183-1191. 

This principle of anhydrous concentrates was named SMEDDS , self micro-emulsifying dmg delivery systems. Such formulations lack the aqueous phase. On dilution, a SMEDDS spontaneously converts to an optically clear, thermodynamically stable microemulsion, which contains the dmg in molecular dispersion. The same principle of a water-free concentrate which leads to a macro -emulsion is called SEDDS, a self-emulsifying dmg delivery system. A recent review on self-dispersing lipid based systems was... 

Kyatanwar AU, Jadhav KR, and Kadam VJ. (2010). Self micro-emulsifying drug delivery system (SMEDDS) Review. Journal of Pharmacy Research, 3, 75-83. 

Mukherjee, T., Plakogiannis, F.M., 2010. Development and oral bioavailability assessment of a supersaturated self-microemulsifying drug delivery system (SMEDDS) of albendazole. J. Pharm. Pharmacol. 62, 1112—1120. 

SEDDs and SMEDDs are used for in situ formation of emulsions/microemulsions in the GI tract. Those systems include an oil solution of the drug, surfactants, cosolvents, and other water-soluble... 

CHALLENGES OF MICROEMULSION-BASED DRUG DELIVERY SYSTEM 10.4.1 Toxicity and Safety of SMEDDS... 

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