Small-volume injectable liquids aqueous solutions

Small-volume injectable liquids are primarily aqueous solutions. However, because many important therapeutic agents are poorly soluble or totally insoluble in water, oily solvents and water-miscible cosolvents are used to produce ready-to-use solutions. 

In order to make it possible the determination of enthalpies of solution of gases in organic liquid solvents, Battino and Marsh [70] set up a modified burette arrangement. This modified technique proved to be effective for the particular systems where small gas solubilities are observed. However the technique was impractical in the case of CO2 dissolution in aqueous solution of amine. This was mainly due to high solubility of carbon dioxide and consequently, large volumes of injected gas. Then Carson... 

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