Small Molecules to Promote Stem Cell Expansion

1 Small Molecules to Promote Stem Cell Expansion 

Much of the early work on the development of small molecules to allow ESC expansion has used murine cells, building on our knowledge of self-renewal 

Human ESCs have been shown to display significant differences to mouse ESCs they do not respond to LIF, instead relying on FGF and activin/nodal signalling. Small molecules identified to allow the expansion of mouse ESCs 

Expansion of Rho kinase Promotes embryonic inhibitor survival of stem cells dissociated 

Expansion of other adult cell populations have also been investigated for potential clinical application, including the expansion of pancreatic p-cells with small molecules such as the Wnt agonist la, indicating a further role for Wnt signalling in pancreatic cell proliferation, and the L-type calcium channel activator 2a, which was observed to exert an additive effect when used in conjunction with a GLP-1 receptor agonist, Exendin-4.  

---

Table 4.1 Selected small molecules to promote stem cell expansion/proliferation. 

---