Strategic approach

When stereochemical complexity is embedded in topological complexity, such as in complex polycyclic structures, the stereochemical strategies which are most effective are those which are linked to both complexities. A decidedly different strategic approach is appropriate for topologically simpler systems. 

The synthesis of cafestol, an antiinflammatory agent which occurs in coffee beans along with related diterpenoids such as actractyloside and kahweol, was accomplished by the same strategic approach which was applied to its companion atractyligenin. 

Marshall, V. C. 1976. The siting and construction of control buildings—a strategic approach. I.Chem.E. Symp. Series, No. 47. 

LX Yu, JR Crison, GL Amidon. A strategic approach for predicting oral drug absorption in humans. Pharm Res 12 S8, 1995. 

While only a snapshot of the proposed biosynthetic picture for complanadine A has been presented above, we considered an alternative approach in our synthetic strategy analysis (as shown below in Fig. 11.3) that also put into focus the close connections between complanadine A, which would arise from a dimerization of the (S-obscurine precursor 21, and the Lycopodium alkaloids lycoposerramine R (23) and fastigiatine (25). The details of this strategic approach are the subject of this chapter. 

In materials chemistry, nanoparticles of noble metals are an original family of compounds. Well-defined in terms of their size, structure and composition, zero-valent transition-metal colloids provide considerable current interest in a variety of applications. Here, the main interest is their application in catalysis. Zerovalent nanocatalysts can be generated in various media (aqueous, organic, or mixture) from two strategic approaches according to the nature of the precursor, namely (i) mild chemical reduction of transition-metal salt solutions and (ii) metal atom... 

Zhou, L., Thompson, R., Song, S., Elhson, D., Wyvratf J.M. A strategic approach to the development of capillary electrophoresis methods for pharmaceutical basic compounds nsing sulfated cyclodextrins. J. Pharm. Biomed. An. 2002, 27, 541-553. 

In Chapter 27, which is available online, a description of the marine organic products in current use is provided along with a consideration of how the structures of these molecules confer predictable physiological activities. This is followed by a discussion of the strategic approaches used to discover and develop marine organic products along with the reasons why new products are so hard to bring to market. Finally, some... 

Evaluation of the relative merits of different treatment techniques or strategic approaches— existing or newly introduced—requires the definition of a reference treatment modality. 

Strategic Approach to International Chemicals Management - www.unep.ch/saicm United Nations Industrial Development Organization - Cleaner Production Programme, w w w. u n i d . rg/cp... 

DETR (Department of the Environment, Transport and the Regions) (1999) Sustainable production and use of chemicals, a strategic approach. The Government s chemicals strategy , Stationery Office, London... 

UNEP (2006) Strategic Approach to International Chemicals Management. UNEP, http //www.saicm.org/ documents/saicm%20texts / SAICM publication ENG.pdf (last accessed 15 September 2011). 

Byrn S, Pfeiffer R, Ganey M, Hoiberg C, Poochikian G. Pharmaceutical solids a strategic approach to regulatory considerations. Pharm Res 1995 12 945-954. 

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