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Small interfering RNAs control siRNAs

Tsutsumi T, Hirayama F, Uekama K, Arima H. Evaluation of polyamidoamine dendti-mer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA). J Control Release 2007 119 349-359. [Pg.436]

In gene silencing, the control occurs at the level of RNA. In a common application, the cell produces mRNA as usual, but the cell also has been enabled to produce a particular microRNA (miRNA) or a small interfering RNA (siRNA) to repress expression of endogenous genes. The miRNA or siRNA then can bind to a particular mRNA and suppress the translation of the mRNA to a protein for specific cellular protein targets. This silencing is achieved by the action of a series of enzymes as described next. [Pg.125]

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See also in sourсe #XX -- [ Pg.176 ]



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Interfering

Interfering RNA

RNA, siRNA

SiRNA

SiRNAs

Small RNA

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