Mechanical behavior of polyurethane-based small-diameter vascular grafts

Research Institute for Materials Science and Technology, INTEMA (UNMdP-CONICET), [Pg.451]

1 Vascular tissues structure, diseases, and current treatments [Pg.451]

Vascular tissues comprise arteries, capillaries, and veins. Due to the risk and impact of vascular diseases in arteries, efforts have been focused on replacement and regeneration strategies. Arteries present a complex structure as they are composed of three layers, intima, media, and adventitia, each with a different composition and function. Additionally, artery composition changes depending on its location. [Pg.451]

The intima is the innermost layer and it is composed mainly of endothelial cells (ECs). This layer controls the molecular transfer inside the wall, provides antithrom-bogenicity, and is involved in homeostasis maintenance, muscular tone, and immunogenic and inflammatory regulation. [Pg.451]

The media is the artery s middle layer, composed of mainly smooth muscle cells (SMCs) in a circumferential arrangement, alternating with elastin sheets and, to a lesser extent, collagen fibers. SMCs become contractile in maturity and are responsible for regulating vessel size. Elastin provides high comphance since it is responsible for high arterial deformation capacity at low pressures. [Pg.451]

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