Skin tumors sebaceous

Of 111 rats given 20mg of DCB hy injection or gastric intuhation 6 days/week for 10-20 months, 17 had tumors of the zymbal gland (a specialized sebaceous gland adjacent to the external ear canal), 13 had mammary tumors, 8 had skin tumors, 5 had malignant lymphomas, 3 had urinary bladder tumors, 3 had salivary gland tumors, and 2 had intestinal tumors no tumors were found in 130 control... 

The pathologic distinction between primary sebaceous carcinoma and metastatic renal cell carcinoma (RCC an important differential diagnostic alternative with a clear-cell appearance) is similar to that made earlier in reference to sweat gland carcinomas. Slow evolution of a solitary skin tumor favors a primary lesion. In addition, immunostaining for podoplanin is effective in this context that determinant is consistently present in sebaceous tumors, whereas it is absent in RCC. CD 10 is potentially seen in both lesional categories. TSS... 

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