Skin disorders case studies

Fluconazole is generally well tolerated. The most common adverse effects are nausea and vomiting. Abnormal liver function tests and slight increases in hepatic enzymes have been reported, and there have been anecdotal reports of hepatitis and hepatic failure. Early studies have shown no changes in testosterone concentrations or in the adrenal response to ACTH. Rashes and a few cases of exfoliative skin disorder have been reported (SED-12,681) and have been seen more frequently in patients with AIDS (29). Alopecia has been reported in a few cases with the use of high doses for prolonged periods of time (SEDA-18, 281). Rare instances of anaphylactoid reactions have been reported (SED-12, 681) (30). Rare instances of hypersensitivity reactions have occurred in other individuals (SEDA-16, 293) (SEDA-17,320). Tumor-inducing effects have not been reported. 

In one Australian study, out of 954 patients with occupational contact dermatitis, 61 % reported having had lost time at the workplace due to their skin disorder [69], As noted in previous section, irritant hand dermatitis as in the case of hand eczema are the most common of all occupational skin disorders reported [72], Also the hands are the primary site of involvement in 80 % of cases of occupational dermatitis, followed by the wrists and forearms [70],... 

The acetylenes and linear furanocoumarins (psoralens) are examples of bioactive secondary metabolites that have been considered undesirable in plant foods due to their toxic effects. Some acetylenes are known to be potent skin sensitizers and irritants, and neurotoxic in high concentrations, but have also been shown to have a pronounced selective cytotoxic activity against various cancer cells. Due to their role in plant defence many acetylenes and psoralens are considered natural pesticides or in some cases phytoalexins since their formation is often induced in plants as a response to external stimuh. Psoralens are photoactivated secondary metabolites that have been used since ancient times to treat human skin disorders. However, the use of these furanocoumarins in medicine has been associated with increased incidence of skin cancer, and a number of studies have also demonstrated that the furanocoumarins can be carcinogenic, mutagenic, photodermatitic and to have reproductive toxicity. 

P2. Paulli, M., Berti, E., Rosso, R., Boveri, E., Kindi, S., Klersy, C., Lazzarino, M., Borroni, G., Menestrina, F., Santucci, M., et al. CD30/Ki-1-positive lymphoproliferative disorders of the skin—Clinicopathologic correlation and statistical analysis of 86 cases A multicentric study from the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Project Group. J. Clin. Oncol. 13, 1343-1354 (1995). 

The Hartnup disease described in 1956 (B2) under the title hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant renal aminoaciduria, and other bizarre biochemical features evidently belongs to the diseases related to inborn errors of metabolism due to inherited differences. As was pointed out by Harris (H3), very often the detection of urinary amino acid metabolites has represented the starting point of the investigation of different genetic biochemical disorders. A recent study (A8) showed that the excess production of indole by colon bacteria in 15 cases of Hartnup disease was due entirely to an increased amount of tryptophan contained in the large bowel, and not to an abnormality of the bacteria themselves. 

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