Skin depigmentation

Dooley TP (1997) Topical skin depigmentation agents current products and discovery of novel inhibitor of melanogenesis. J Dermatol Treat 8 ... 

During the industrial handling of 4-methoxyphenol, two of eight process workers developed skin depigmentation. ... 

Furanocoumarlns have a number of scientifically interesting and even economically and medicinally Important actions. They are effectively used in human medicine in the treatment of vitiligo (skin depigmentation, leukoderma) ( ) and psoriasis (10,11), and have shown promise against certain other human maladies (12-15). Plants that contain furanocoumarlns are known to cause acute photosensltlzatlon (phytophotodermatltls) in man (2,16). 

Skin depigmentation effect. Extract of the dried seed, administered externally to adults at a dose of 5%, was active. Skin-lightening cosmetics contained extract of Coffea arabica seeds (containing chlorogenic acid) as melanin-formation inhibitors. The extract has been incorporated into cosmetics for skin-aging prevention or into hair preparations for hair protection. Biological activity reported has been patented . 

Complications after steroid injection are minimal but can occur.The patient can expect slight discomfort at the injection site and occasionally subcutaneous white (steroid) deposits in the treated area. Depigmentation of the eyelid at the injection site, especially in dark-skinned individuals, and temporary skin atrophy can also occur. Skin depigmentation can be minimized by using a transconjunctival rather than a transepidermal injection in persons of color. When depigmentation occurs, it is... 

Thiotepa is a carcinogen in humans (group 1). Chronic exposure to thiotepa may cause skin depigmentation and allergic reactions as well as effects seen with acute exposure. 

Copper Neutropenia, leukopenia, hypochromic anemia, osteoporosis, hair and skin depigmentation, dermatitis, anorexia, diarrhea, mental deterioration, hypercholesterolemia Wilson s disease liver cirrhosis, diarrhea, vomiting, metallic taste Decreased high iron or vitamin C intake, corticosteroid use Increased infection, rheumatoid arthritis, pregnancy, oral contraceptives, decreased biliary excretion... 

HUMAN HEALTH RISKS Acute Risks irritation of mucous membranes, upper respiratory tract, eyes and skin may cause allergic reaction bums colored urine muscle twitch CNS excitement suffocation delirium increased pulse rate without fall in blood pressure respiratory failure Chronic Risks dermatitis anemia skin depigmentation effects on kidney and eyes corneal and conjunctival discoloration cancer. 

Hydroxybenzofuran (284) has found application in the treatment of melasma as a topical skin depigmentation agent <93EUP524108>. An isomer (285) has been used as a coupling agent for oxidative hair dyes <92EUP506549>. Acid (286), extracted from Cnidium monnieri, reportedly enhanced sexual activity in mice. It has been patented for use in the treatment of physical and mental stress <92JAP(K)0459733>. 

Hypopigmentation/hypomelanosis refers to a reduction in melanin content relative to the individual s normal skin. Depigmentation is a term implying loss of pre-existing melanin pigmentation (Mosher et al. 1993)- Vitiligo should be reserved for idiopathic or hereditary acquired leukoderma or depigmentation... 

BIOLOGICAL ACTIVITY Antimelanoma and skin depigmentation [6778] choleretic [6715] anthelmintic [6779] trypanosoma brucei brucei response [6780] bactericide [6781]. 

Notes C-Deuteration [6447] acidity of methylene proton [6446] skin depigmentation [6778]. 

BIOLOGICAL ACTIVITY Catechol 0-methyltransferase inhibitor [8024,8025, 8040] pharmacology [6828] antimelanoma and skin depigmentation [6778] antihypertensive [8041] tyrosine hydroxylase inhibition [8042]. 

Because LF(Ls are potent photoactive compounds, they have been used clinically to treat human skin disorders such as skin depigmentation (vitiligo), psoriasis, mycosis fungoides, polymorphous photodermatitis and eczema. About 40 mg of psoralen (79) administered... 

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