Skeletal muscle functions

Skeletal muscle functions under both aerobic (resting) and anaerobic (eg, sprinting) conditions, so both aerobic and anaerobic glycolysis operate, depending on conditions. 

Lopes, J. M., Aubier, M., Jardin, J., Aranda, J. V., and Macklem, P. T., Effects of caffeine on skeletal muscle function before and after fatigue, Journal of Applied Physiology, 54, 1303, 1983. 

Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS (2000) Skeletal muscle function and water permeabihty in aquaporin-4 deficient mice. Am J Physiol Cell Physiol 278 C1108— Cl 115... 

The clinical importance of a differential nerve block is that certain sensory modalities may be blocked without the loss of motor function. Fortuitously, the most susceptible modality is pain because analgesia is usually the desired effect. If the dosage and administration of the anesthetic is optimal, it will produce analgesia without any significant loss of skeletal muscle function. This fact may be advantageous if motor function is required, such as during labor and delivery.14 If... 

Cameron NE, Cotter MA, Robertson S. Essential fatty acid supplementation. Effects on peripheral nerve and skeletal muscle function and capillarization in streptozotocin-induced diabetic rats. Diabetes 1991 40 532-539. 

Moderate aerobic exercise to improve cardiovascular conditioning is beneficial to maintain a slower heart rate, improve cardiac reserve, and maintain skeletal muscle function. Isometric exercise should be avoided. ... 

Myasthenia gravis is a disease of the neuromuscular junction that affects skeletal muscle function. 

Multiple sclerosis and motor neuron disease are diseases of the nervous system, but are included here because major effects of these diseases are on skeletal muscle function. 

Strictly speaking, motor neuron disease and multiple sclerosis are diseases of the nervous system, rather than the musculoskeletal system. However, although these conditions are relatively rare, they are included here because the consequences of them affect skeletal muscle function and because health care professionals are likely to be involved in the care of patients with these two conditions. 

L-dopa is taken into both dopaminergic and noradrenergic nerve terminals, both in the CNS and periphery. Thus, peripheral levels of dopamine and norepinephrine may increase with administration of the drug, resulting in effects on the cardiovascular system, renal blood flow, and skeletal muscle function. 

Prolonged, high doses of acetylcholinesterases (AChEs) have been shown to cause ultra-structural changes in skeletal muscle and motor endplate in experimental animals. In addition, the increase in available ACh initiates a negative feedback response, resulting in a decrease in ACh synthesis, and a decrease in post-junctional receptor sensitivity and density. Withdrawal of terminal neuronal branches from the motor endplate has been observed as well. These changes may result in an observable decrease in skeletal muscle function. 

Soderberg G.L. 1992. Skeletal muscle function. In D.P. Currier and R.M. Nelson (Eds.), Dynamics of Human Biologic Tissues, pp. 74-96. Philadelphia, FA Davis Company. 

At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been reported which indicate clear differences in the pathways of ATP metabolism. The widening of the field of interest is also illustrated by the recent work on infectious disease exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being developed. 

Farmer JA. The effect of statins on skeletal muscle function the STOMP trial. Curr Atherosder Rep 2013 15 347. 

Alkalosis, either metabolic or respiratory, does not affect skeletal muscle function (40). In contrast, whether acidosis, either metabolic or respiratory, impairs respiratory muscle function remains controversial. 

Abnormal gas exchange, malnutrition, and prolonged use of controlled ventilation, leading to selective diaphragmatic muscle atrophy, add to peripheral and respiratory muscle weakness (38). Many of the above reasons make it likely that patients will benefit from PT that targets respiratory and skeletal muscle function, although clearer evidence of positive outcomes is still required (53). Inspiratory muscle training has been shown to facilitate... 

Clanton, T.L., Zuo, L., Klawitter, P, 1999. Oxidants and skeletal muscle function physiologic and pathophysiologic implications. Proc. Soc. Exp. Biol. Med. 222, 253-262. 

Marks, A. R. Type 1 ryanodine receptor-based methods for treating defective skeletal muscle function during heart failure and for drug screening. PCT Int. Appl. WO 2004080283, 2004 Chem. Abstr. 2004, 141, 271568. 

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