Single particle mass spectrometry

K. A. Prather. 2002, Overview of Real-Time Single Particle Mass Spectrometry Methods. Presen-tation. Workshop on National Seciwity and Homeland Defense, Irvine, CA. (See Appendix D.)... 

Overview of Real-Time Single Particle Mass Spectrometry Methods... 

OVERVIEW OF REAL-TIME SINGLE PARTICLE MASS SPECTROMETRY METHODS... 

Carson, P. G K. R. Neubauer, M. V. Johnston, and A. S. Wexler, On-Line Chemical Analysis of Aerosols by Rapid Single-Particle Mass Spectrometry, J. Aerosol Sci., 26, 535-545 (1995). 

Noble C. A. and Prather K. A. (2000) Real-time single particle mass spectrometry a historical review of a quarter century of the chemical analysis of aerosols. Mass. Spectrom. Rev. 19, 248-274. 

Characterization of Nanoparticle Composition and Reactivity by Single Particle Mass Spectrometry... 

Smith, G.D., Woods, E., DeForest, C.L., Baer, T., Miller, R.E. (2002) Reactive Uptake of Ozone by Oleic Acid Aerosol Particles Application of Single-particle Mass Spectrometry to Heterogeneous Reaction Kinetics. J. Phys. Chem. A 106 8085-8095. 

Woods E, Smith GD, Miller RE, Baer T. 2002. Depth profiling of heterogeneously mixed aerosol particles using single-particle mass spectrometry . Anal. Chem. 74(7) 1642-1649. 

Single-particle mass spectrometer Vaporization, ionization, and time-of-flight mass spectrometry -1-... 

Figure 8. Image and diffraction pattern from an (100) epitaxial. specimen of gold prepared in an unbaked UHV evaporator by depo.sition onto KOI and then transfer onto amorphous carbon. Here water vapour was the dominant residual gas (determined by mass spectrometry). The particles are square pyramidal single crystals.

The use of the particle-beam interface for introduction of samples into a mass spectrometer (PB-MS), without chromatographic separation, was shown by Bonilla [55] to be a useful method for analysis of semi-volatile and nonvolatile additives in PC and PC/PBT blends. The method uses the full power of mass spectrometry to identify multiple additives in a single matrix. The usefulness, speed and simplicity of this approach were illustrated for AOs, UVAs, FRs, slip agents and other additives. 

My research focuses on aerosol particles between 0.1 om and 10 om. Bacteria, though most often seen with optical devices, fall within this size range where detection by mass spectrometry is ideal. Single particles down to 12 nm have been detected by mass spectrometry so that viruses, though considerably smaller than bacteria, can also be analyzed (see Figure D.5). 

Depth profiling of single airborne particles has been reported by Carson et al. (1995, 1997a), who showed that the use of variable laser fluences in single-particle laser ionization mass spectrometry can be used to probe thin films on particles in laboratory systems. At low laser intensities, only the surface layer is volatilized and ionized, whereas the entire particle can be vaporized and detected at higher intensities. 

Hinz, K.-P., R. Kaufmann, and B. Spengler, Simultaneous Detection of Positive and Negative Ions from Single Airborne Particles by Real-Time Laser Mass Spectrometry, Aerosol Sci. Technol., 24, 233-242 (1996). 

McKeown, P. J., M. V. Johnston, and D. M. Murphy, On-Line Single-Particle Analysis by Laser Desorption Mass Spectrometry, Anal. Chem., 63, 2069-2073 (1991). 

Stoffels, J. J., and J. Allen, Mass Spectrometry of Single Particles In Situ, in Physical and Chemical Characterization of Individual Airborne Particles (K. R. Spumy, Ed.), Chap. 20, pp. 380-399, Ellis Horwood, Chichester, 1986. 

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