Single-particle analysis, mass spectrometry

McKeown, P. J., M. V. Johnston, and D. M. Murphy, On-Line Single-Particle Analysis by Laser Desorption Mass Spectrometry, Anal. Chem., 63, 2069-2073 (1991). 

More ambitious attempts at measuring the heterogeneity of the atmospheric aerosol have been undertaken as well. Single-particle analysis by mass spectrometry was demonstrated by Sinha and co-workers (31, 32). In this technique, an aerosol sample is introduced into a vacuum chamber in the form of a particle beam. The particles are injected into a Knudsen cell oven, where they undergo many collisions with the cell wall and are ultimately vaporized and ionized. The ions are then mass-analyzed with a quad-rupole or sector mass spectrometer. So that individual particles can be analyzed, the flux of particles into the Knudsen cell is limited so that coincidence errors are minimized. Ion pulses from individual particles allow the determination of the amount of the species being analyzed in the particular particle. The sensitivity of the technique is limited. For sodium, the detection... 

McKeown PJ, Johnston MV, Murphy DM. 1991. Online single-particle analysis by laser desorption mass-spectrometry . Anal. Chem. 63(18) 2069-2073. 

The use of the particle-beam interface for introduction of samples into a mass spectrometer (PB-MS), without chromatographic separation, was shown by Bonilla [55] to be a useful method for analysis of semi-volatile and nonvolatile additives in PC and PC/PBT blends. The method uses the full power of mass spectrometry to identify multiple additives in a single matrix. The usefulness, speed and simplicity of this approach were illustrated for AOs, UVAs, FRs, slip agents and other additives. 

Carson, P. G K. R. Neubauer, M. V. Johnston, and A. S. Wexler, On-Line Chemical Analysis of Aerosols by Rapid Single-Particle Mass Spectrometry, J. Aerosol Sci., 26, 535-545 (1995). 

Noble C. A. and Prather K. A. (2000) Real-time single particle mass spectrometry a historical review of a quarter century of the chemical analysis of aerosols. Mass. Spectrom. Rev. 19, 248-274. 

Single-Particle Chemical Analysis by Mass Spectrometry... 

Pointurier, F., Pottin, A.C., and Hubert, A. (2011). Application of nanosecond-UV laser ablation—Inductively coupled plasma mass spectrometry for the isotopic analysis of single submicrometer size uranium particles, Ana/. Chem. 83,7841-7848. 

Mass spectrometry can be the ideal detector for liquid chromatography because it offers both universality and the required selectivity for complex analytical problems. The two most popular types of interface for the benchtop single quadmpole LC-mass spectrometer are the particle beam interface and the atmospheric pressure ionisation interface. The particle beam interface is used to generate electron ioinsation spectra and the API interface is used to generate either electrospray or atmospheric pressure chentical ioinsation. This comprehensive article supplies a detailed analysis of a study in which organic extractable from polypropylene was used as the model analyte to demonstrate how the information obtained separately tfom El and API can be complementary. Seven compounds were separated and detected by both MS detectors. 35 refe. 

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