Single-lung transplantation

McCarthy PM, Wang N, Birchfield F, Mehta AC. Air embolism in single-lung transplant patients after central venous catheter removal. Chest 1995 107(4) 1178-9. 

Walder B, Briindler M-A, Spdiopoulos A and Romand JA (1997). Successful single-lung transplantation after paraquat intoxication. Transplantation 64(5), 789-791. 

In a case-control study in 543 lung transplant recipients, 17 (3.1%) developed squamous cell carcinomas Mer a median follow-up of 36 months [62 ]. The median time to development was 19 months after transplantation. Risk factors by univariate analysis included older age, residence in locations with high levels of sun exposure, single-lung transplantation, and duration and cumulative dose of voriconazole. The duration of voriconazole therapy and residence in locations with high sun exposure were independent risk factors by multivariate analysis. The lesions were located on the head and neck in 94% of cases and 53% had multiple lesions. After surgery at least one further independent lesion developed in 47% of patients. There was local spread and distant metastases in 7% of cases. There were no deaths. 

Zaporozhan J, Ley S, Gast KK et al. Functional analysis in single-lung transplant recipients a comparative study of high-resolution CT, He-MRI, and pulmonary function tests. Chest 2004 125 173-181. 

Grgic A, Lausberg H, Heinrich M, et al. Progression of fibrosis in usual interstitial pneumonia serial evaluation of the native lung after single lung transplantation. Respiration 2007 (e-Published). 

Lok SS, Smith E, Doran HM, et al. Idiopathic pulmonary fihrosis and cyclosporine a lesson from single-lung transplantation. Chest 1998 114 1478-1481. 

Barberis M, Mazari S, Tironi A, et al. Recurrence of primary disease in a single lung transplant recipient. Transplant Proc 1992 24 2660-2662. 

Verleden GM, Sels F, Van Raemdonck D, et al. Possible recurrence of desquamative interstitial pneumonitis in a single lung transplant recipient. Eur Respir J 1998 11 971-974. 

Robinson DS, Geddes DM, HanseU DM, et al. Partial resolution of acute interstitial pneumonia in native lung after single lung transplantation. Thorax 1996 51(11) 1158-1159. 

Bittmann I, Rolf B, Amann G, et al. Recurrence of lymphangioleiomyomatosis after single lung transplantation new insights into pathogenesis. Hum Pathol 2003 34(l) 95-98. 

O Brien JD, Lium JH, Parosa JF, et al. L3miphangioleiomyomatosis recurrence in the allograft after single lung transplantation. Am J Respir Crit Care Med 1995 151 2033-2036. 

A 65-year-old Caucasian man with a left single lung transplant took voriconazole (200 mg twice daily) for pulmonary aspergillosis after 9 months therapy, a follow-up chest computed tomography showed no infectious disease, hut revealed multifocal periostitis in the axial and appendicular skeleton that was not seen initially [43A]. Bone pain was not assessed because the patient had severe dementia. The authors discuss the case and review published case reports and series on voriconazole-induced periostitis. 

In 1983 the Toronto Lung Transplant Group (1986) performed the first single-lung transplantations for patients with end-stage chronic obstructive pulmonary disease and advanced pulmonary fibrosis. Their technique was later expanded to bilateral sequential single-lung transplantation for patients with bronchiectasis and cystic fibrosis. 

Single-lung transplantation is the most common form of transplantation used in patients with COPD and IPF. Due to organ scarcity other TX techniques, such as lobar and split lung transplantation, are used and allow the use of hving donors especially in younger patients. 

Fig. 5.2.2. Transverse CT section in a single-lung transplant recipient. Native lihrotic lung (right) shows increased density, whereas the density of the transplanted left lung is normal...

Fig. 5.2.4. Transverse CT scan in double-lung transplant recipient with two sequentially performed single-lung transplants. Lungs of different donors in the same patient show different sizes and densities...

Fig. 5.2.15. Transverse CT section after right single-lung transplantation in inspiration (left) and expiration (right). Native emphysematous lung does not change in density between inspiration and expiration, suggestive of extensive air trapping. Transplanted right lung increases in density in expiration and shows only a peripheral area of air trapping...

Bjortuft 0, Johansen B, Boe J, Foerster A, Holter E, Geiran 0 (1993) Daily home spirometry facilitates early detection of rejection in single lung transplant recipients with emphysema. Fur Respir J 6 705-708... 

Bjortuft 0, Foerster A, Boe J, Geiran O (1994) Single lung transplantation as treatment for end-stage pulmonary sarcoidosis recurrence of sarcoidosis in two different lung allografts in one patient. J Heart Lung Transplant 13 24-29... 

Calabrese F, Giacometti C, Rea F, Loy M, Sartori F, Di Vittorio G, Abudureheman A, Thiene G, Valente M (2002) Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation 74 1643-1645... 

Lee KH, Martich GD, Boujoukos AJ, Keenan RJ, Griffith BP. Predicting ICU length of stay following single lung transplantation. Chest 1996 110 1014-1017. 

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