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Sinemet

Levodopa is a chemical formulation found in plants and animals that is converted into dopamine by nerve cells in the brain. Levodopa does cross die blood-brain barrier, and a small amount is dien converted to dopamine. This allows the drug to have a pharmacologic effect in patients witii Parkinson s disease (Pig. 29-1). Combining levodopa witii another drug (carbidopa) causes more levodopa to reach die brain. When more levodopa is available, the dosage of levodopa may be reduced. Carbidopa has no effect when given alone. Sinemet is a combination of carbidopa and levodopa and is available in several combinations (eg, Sinemet 10/100 has 10 mg of carbidopa and 100 mg of levodopa Sinemet CR is a time-released version of die combined drugs). [Pg.265]

Neodopaston (Sankyo)-comb. with levodopa USA Atamet (Athena) Sinemet (Du Pont)... [Pg.344]

Levodopa (Larodopa , Dopar ) LD metabolized to DA Start with Sinemet 1/2 tab (1 00 mg LD, 25 mg CD) twice daily for 1 week,... [Pg.479]

Tolcapone (Tasmar ) Peripherally blocks COMT metabolism of DA some central activity Start with 1 00 mg with first Sinemet dose once daily if symptoms continue, increase to 2 and then 3 times daily, then to 200 mg each dose usual MD is 1 00 three times daily to minimize risk of side-effects... [Pg.479]

Entacapone (Comtan ) Peripherally blocks COMT metabolism of DA Take a 200-mg tab with each Sinemet dose up to 8 tabs daily usual MD is 200 mg 3-4 times daily decrease dose by 50% with hepatic impairment... [Pg.479]

Use rapid-dissolving tablet (Parcopa ), crush Sinemet , or make liquid Sinemet ... [Pg.483]

Decrease dose and increase frequency of standard Sinemet ... [Pg.483]

Decrease risk by lowering Sinemet dose when adding other PD medications... [Pg.483]

Add Sinemet CR or dopamine agonist at bedtime if having nighttime offs... [Pg.483]

Morning Sinemet dose should be immediate-release with or without CR... [Pg.483]

Carbidopa therefore inhibits the conversion of L-dopa to dopamine in the peripheral tissues and the blood while leaving it unchanged in the brain. The combination of L-dopa and carbidopa is marketed as Sinemet and was the treatment of choice for parkinsonism for many years. Note the structural similarity between carbidopa and L-dopa. Carbidopa looks enough like L-dopa to occupy the L-dopa site on the decarboxylase. At the same time, the subtle structural differences render carbidopa indifferent to the enzyme. It is an inhibitor, not a substrate. [Pg.307]

Dopamine-Boosting Medications. Levodopa/carbidopa (Sinemet), bromocriptine (Parlodel), pramipexole (Mirapex), and ropinirole (Requip) increase dopamine nenrotransmission in the brain by one or another mechanism. These medications do not reliably induce sleep, and in some patients are activating. They are certainly not true sedative-hypnotics. They are most often used by neurologists to treat Parkinson s disease. [Pg.272]

Dopamine activity can be enhanced in one of four main ways. Medications can stimulate dopaminergic nerve cells to release dopamine into the synapse. This is the way that stimulants such as methylphenidate (Ritalin), dextroamphetamine (Dexe-drine), and dextroamphetamine/amphetamine (Adderall) work. In addition, certain drugs of abuse, notably cocaine and methamphetamine, act in part in this way. Providing more of the raw material that nerve cells use to manufacture dopamine can also increase dopamine activity. This is the approach that neurologists use when they prescribe L-DOPA (Sinemet) to patients with Parkinson s disease. Nerve cells convert L-DOPA into dopamine. L-DOPA otherwise has little place in the treatment of psychiatric disorders. Dopamine activity can also be increased by medications that directly stimulate dopamine receptors. Bromocriptine, another medication used to... [Pg.363]

Sinemet 10/100 Sinemet 25/100 Sinemet 25 0 Antiparkinsonian Tab Carbidopa 10 mg, levodopa 100 mg Tab Carbidopa 25 mg, levodopa 100 mg Tab Carbidopa 25 mg, levodopa 250 mg 1 tab tid-qid dyskinesia, nausea, mental status changes, paranoia, psychosis, depression. [Pg.72]

Serevent 60 Seroqud 59 Sertraline 61 Setzone 51 Sevelamer 61 Sibutramine 61 Simvastatin 61 Sinemet 82 Sinequan 31 Singulair 50 Sirolimus 61 Skelid 64 Slo-bid 64 Slophyllin 64 Slow Mag 47 SIcw-K 57... [Pg.107]

Carhidopa/ Levodopa Sinemet 25/100 and 50/200 mg extended-release tablets... [Pg.99]

Larodopa, Dopar, Dopaidan Madopar, Prolopa Sinemet... [Pg.342]

See other pages where Sinemet is mentioned: [Pg.893]    [Pg.355]    [Pg.239]    [Pg.239]    [Pg.239]    [Pg.1741]    [Pg.344]    [Pg.344]    [Pg.344]    [Pg.1165]    [Pg.479]    [Pg.483]    [Pg.483]    [Pg.483]    [Pg.483]    [Pg.483]    [Pg.629]    [Pg.645]    [Pg.645]    [Pg.64]    [Pg.153]    [Pg.154]    [Pg.154]    [Pg.336]    [Pg.364]   
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Sinemet - Carbidopa

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