Simultaneous optimization methodology

Finally, if the problem does not fall into either of these two categories, we can attempt to apply the simultaneous optimization methodology proposed by Derringer and Suich (1980), which can be quite usefiil when used with care. 

In principle, the analytical results obtained by the GPC spin column/HPLC ESI-MS methodology described in this chapter should be similar to the results obtained using the tandem chromatographic method of GPC/reversed-phase HPLC ESI-MS described in Chapter 3. There are practical advantages for each method. Since each of the chromatographic and mass spectral steps are done serially for the GPC spin column/HPLC ESI-MS methodology, each of the steps can be performed and optimized individually. In the event of mass spectrometer failure, the production of spin column eluate samples can proceed and samples can be stored for future analysis. In contrast, the parallel methodology of tandem GPC/ reversed-phase HPLC ESI-MS requires the simultaneous optimization of multi-... 

For instance, Yadav and Ahuja prepared nanoparticles using gum cordia as the polymer and to evaluate them for ophthalmic delivery of fluconazole. A w/o/w emulsion containing fluconazole and gum cordia in aqueous phase, methylene chloride as the oily phase, and dioctyl sodium sulfosuccinate and polyvinyl alcohol as the primary and secondary emulsifiers, respectively, were cross-linked by the ionic gelation technique to produce a fluconazole-loaded nanoreservoir system. The formulation of nanoparticles was optimized using response surface methodology. Multiple response simultaneous optimizations using the desirability approach were used to find optimal experimental conditions. The optimal conditions were found to be concentrations of gum cordia (0.85%, w/v), di-octyl sodium sulfosuccinate (9.07%, w/v), and fluconazole (6.06%, w/v). On comparison of the optimized nanosuspension formulation with commercial formulation, it was found to provide comparable in vitro corneal permeability of... 

In this paper the problem of simultaneous decoupling and pole placement without canceling invariant zeros was considered as a system of nonlinear equations. A general solution procedure was developed based on a global optimization methodology that allows the determination of all feasible solutions of such a system of nonlinear equations. 

In the current work, we present a comprehensive approach to the problem dynamic mathematical models for simultaneous reactions media, numerical methodology as well as model verification with experimental data. Design and optimization of industrially operating reactors can be based on this approach. 

Another optimization approach was followed by Wagner [68 ]. Wagner developed a methodology for performing simultaneous model parameter estimation and source characterization, in which he used an inverse model as a non-linear maximum likelihood estimation problem. The hydrogeologic and source parameters were estimated based on hydraulic head and contaminant concentration measurements. In essence, this method is minimizing the following ... 

Abad-Garcia, B. Berrueta, L.A. Lopez-Marquez, D.M. Crespo-Ferrer, I. Gallo, B. Vicente, F. 2007. Optimization and validation of a methodology based on solvent extraetion and liquid chromatography for the simultaneous determination of several polyphenolie families in fruit juices. J. Chromatogr. A 1154 87-96. 

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