Silica human carcinogen

Toxicology ACGIH TLV/TWA (8 h) 10 mg/m (total) OSHA PEL 0.1 mg/m (quartz) nuisance dust may cause si. irritation to eyes, by inh. chronic exposure may damage lungs contains < 1% cryst. cryst. silica, a probable human carcinogen TSCA listed Precaution Minimize dusting prevent static discharges may be slippery when wet... 

Toxicology ACGIH TLV/TWA (8 h) 3 mg/m (respirable particulates), 0.05 mg/m (respirable quartz) LD50 (oral, rat) > 5 g/kg may cause mod. mech. eye irritation chronic exposure may cause lung damage cryst. silica, a human carcinogen, may cause silicosis TSCA listed... 

The lARC has determined that there is sufficient evidence for the carcinogenicity of crystalline silica to experimental animals and to humans. ... 

International Agency for Research on Cancer (IARC), Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Silica and Some Silicates (Lyon, France WHO, 1987), pp. 59-145. 

IARC Monographs on the Evaluation of the carcinogenic risk of chemicals to humans, Silica, some silicates, coal dusts para-aramidfibrils, vol. 68 (Lyon, France, 1997). 

SAFETY PROFILE Human systemic effects by inhalation fibrosing alveolitis (growth of fibrous tissue in the lung), unspecified respirator system effects, and unspecified effects on the nose. Questionable carcinogen with experimental carcinogenic data. Long considered a nuisance dust (depending on silica content). When heated to decomposition it emits toxic fumes of SOx. See also CALCIUM SULFATE, CALCIUM COMPOUNDS, and SULFATES. 

CONSENSUS REPORTS lARC Cancer Review Group 3 IMEMDT 7,341,87 Animal Inadequate Evidence IMEMDT 42,209,88 Human Inadequate Evidence IMEMDT 42,209,88. Reported in EPA TSCA Inventoiyu SAFETY PROFILE Poison by intraperitoneal, intravenous, and intratracheal routes. Moderately toxic by ingestion. An inhalation hazard. Much less toxic than oy stalline forms. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. Does not cause silicosis. See also other silica entries. 

SAFETY PROFILE Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intratracheal route. An inhalation hazard. Human systemic effects by inhalation cough, dyspnea, fibrosis. About twice as toxic as silica in causing silicosis. See also other silica entries. 

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