Sifter-top container

A topical powder product may be marketed in a sifter-top container made of flexible plastic tubes or as part of a sterile dressing (e.g., antibacterial product). The topical formulations in a collapsible tube can be constructed from low-density polyethylene (LDPE), with or without a laminated material. Normally, there is no product contact with the cap during storage. Thus usually there is no cap liner, especially in collapsible polypropylene screw caps. Normally separate applicator devices are made from LDPE. Product contact is possible if the applicator is part of the closure, and therefore an applicator s compatibility with the drug product should be established, as appropriate (e.g., vaginal applicators). 

The substances should be spread out in a thin layer so that the heat can penetrate well. If they can be sterilised at the same regimen and no interactions will take place during sterilisation, then they should be mixed before sterilisation. Otherwise they should be mixed after sterilisation, asepti-cally. The mixture is not sieved anymore. The powders are packaged in a sterile sifter-top container. 

A sifter-top container (or a powder castor) is ajar that has a sifter top (this is a closure with small diameter openings to apply a powder onto the skin) and a lid. The sifter-top container is made of plastic, usually polypropylene. The sifter-top container can be filled via the top, after taking the sifter-top applicator off or via a snap-on base. Sifter-top containers are available in the volumes of 50 and 100 mL. 

A jar can be provided with a sifter-top usually the jar and the sifter top form one unit ( sifter-top container [43]), which is filled from the bottom (see also Sect. 24.4.7.1). 

A jar is defined as a container, without a pronounced neck, with a wide opening at the top and a more-or-less flat bottom . Jars are frequently reclosable and generally suitable for semisolid and solid pharmaceutical forms [26]. An important difference between a bottle (Sect. 24.4.1) and a jar, is that the jar does not have a neck. The jar for tablets is named separately as a tablet container. Ajar with a sifter top is used for powders for cutaneous application. 

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