Sidewall formulation, model

In a study on the effect of different pharmacological adjuvants on the performance of hyaluronic acid for POA prevention, a rat sidewall model, was used by Shalaby and co-workers to determine adhesion scores associated with HA formulations containing ... 

Results of all segments of the study were compared with a suitable HA control as shown in Tables 13.1, 13.2, and 13.3. The cumulative adhesion scores depicted in Table 13.1 indicate that NP in HA formulations had little effect in preventing adhesion using the rat sidewall model. The data in Table... 

Postsurgical Adhesion Data at One Week with HA/Interleuken-4 (IL-4) Formulations and Placebos Using Sidewall Model with Silk Sutures... 

This study is designed to compare the effect of ftie gel-former selected in Section 13.3.4.2 on POA wifti a size 6-0 silk suture/saline, HA, and C-TA as basic barrier and positive controls, respectively. The adhesion formation was studied using a rat sidewall model. The abdominal cavity was entered into in female Sprague-Dawley rats through a small midline incision. A 1-cm2 area of peritoneal sidewall was excised wifti a scalpel blade. The 6-0 silk was then sutured aroimd the perimeter of ftie excised area with a square knot at each corner. Aliquots of either the gel-former (100 pL) or the controls (1 mL) were injected on tiie excised site. One week postoperative, the adhesion prevention score was recorded for the different formulations on a scale of 0 to 10. A score of 10 represents maximum adhesion whereas 0 reflects the absence of any adhesions. Adhesion rating criteria were based on the work by Bums et al. ... 

An optimized rat sidewall model can be used reproducibly to evaluate antiadhesion formulations in conjxmction with an adopted composite score and multiple photographic documentation of the surgical site. 

Polybutadiene and natural rubber are blended in tire sidewalls to improve fatigue resistance, cut growth resistance, and improve abrasion resistance to minimize the effect of curb scuffing. Figure 4.7 shows atomic force micrographs (AFMs) of the model tire sidewall compound formulation given in Table 4.8. Many tire compounds are composed of two or more elastomer blends. Depending on the types of elastomers these blends may be ... 

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