Sialoglycoprotein

Figure 47-2. Structures of two 0-linked oligosaccharides found in (A) submaxillary mucins and (B) fe-tuin and in the sialoglycoprotein of the membrane of human red blood cells. (Modified and reproduced, with permission, from LennarzWJ The Biochemistry of Glycoproteins and Proteoglycans. Plenum Press, 1980.)...

It is now well established that the MN blood-group antigens are situated99-101 on the major sialoglycoprotein (glycophorin A) of the erythrocyte membrane. The complex, antigenic structure resides within the first five amino acid residues from the N-terminal portion of the molecule three of these residues are glycosylated. 

This enzyme [EC 3.4.24.57], also known as O-sialoglyco-protein endopeptidase and glycoprotease, catalyzes the hydrolysis of O-sialoglycoproteins for example, it cleaves the Arg — Asp peptide bond in glycophorin A. 

R. Codd, J. A. Irwin, and P. A. Lay, Sialoglycoprotein and carbohydrate complexes in chromium toxicity, Curr. Opin. Chem. Biol., 7 (2003) 213-219. 

Scheme 4.—Induction and Cooperation of the Sialic acid-specific Enzymes Siali-dase, Acylneuraminate Pyruvate-lyase, and Neu5Ac-permease (hypothetical) in Clostridium perfringens. [Key , sialoglycoprotein , free sialic acid f—at>, ...

J. Alois and A. Veyriirea, Synthesis of 0-fJ-D galnctopyranosyl-(l-4)-0-2-acetamido-2-deoxy-f3-D-glucopyranosyl-(l-3 -r>-maniiose, a postulated trisaccharide of human erythrocyte membrane sialoglycoprotein, J. Chan. Soc. Perkin Thins. 1 577 (1981). 

Snow, L. D., Colton, D. G. and Carraway, K. L. 1977. Purification and properties of the major sialoglycoproteins of the milk fat globule membrane. Arch. Biochem. Biophys. 179, 690-697. 

Erythrocyte sialoglycoprotein Erythrocyte sialoglycoprotein digested with 18 15... 

Lectin-reactive glycoproteins of the erythrocyte membrane have been studied extensively. Of these, the major sialoglycoprotein has... 

Oxidised LDL in the artery wall initiates a series of reactions designed to repair the damage it causes. Initial damage triggers an inflammatory response. Monocytes enter the artery waU from the bloodstream, with platelets adhering to the area of insult. This may be promoted by induction of factors such as vascular ceU adhesion molecule 1 (VCAM-1), a cell-surface sialoglycoprotein that is expressed by cytokine-activated endothelium. This membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of atherosclerosis and rheumatoid arthritis. 

The sialic acid (N-acetylneuramiiuc acid) of gangliosides and sialoglycoproteins can be A-glycolyl or A-acetyl, and particularly in the context of the lectins that bind such glycoconjugates, this reality is of evolutionary significance (54). Many modifications of sialic acid (primarily O-acetylation at the 7,8,9... 

Spiegel S. Fluorescent derivatives of ganglioside GMl function as receptors for cholera toxin. Biochemistry 1985 24 5947-5952. Gahmberg CG, Andersson LC. Selective radioactive labeling of cell surface sialoglycoproteins by periodate-tritiated borohydride. J. Biol. Chem. 1977 252 5888-5894. 

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