Sialidase Trypanosoma cruzi

Schroven A (2007) Synthesis and investigations on modified neuraminic acid donors for regio-and stereoselective sialylation with trans sialidase (Trypanosoma cruzi). PhD thesis, University of Hamburg... 

F. Vandekerckhove, S. Schenkman, L. Pontes de Carvalho, S. Tomlinson, M. Kiso, M. Yoshida, A. Hasegawa, and V. Nussenzweig, Substrate specificity of the Trypanosoma cruzi trans-sialidase, Glycobiology 2 541 (1992). 

A. C. C. Frash, Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi, Parasitol. Today, 16 (2000) 282-286. 

T. cruzi small mucin-like gene family TcTS, Trypanosoma cruzi trans-sialidase THF, tetrahydrofuran TMSOTf, trimethylsilyl trifluoromethanesulfonate TRR, Thr-rich region TSSA, trypomastigote small surface antigen UDP, uridine diphosphate VSG, variant surface glycoprotein. 

SCHEME 12. Selective sialylation of 2,3-di-0-(/i-D-galactopyranosyl)-i)-galactose catalyzed by Trypanosoma cruzi trans-sialidase. 

SCHEME 20. /Y-(il ycoIyIncuraminic acid transfer by Trypanosoma cruzi trans-sialidase from donors 107 and 108 to lactitol. 

R. Agusti, A. S. Couto, O. Campetella, A. C. C. Frasch, and R. M. de Lederkremer, Structure of the glycosylphosphatidylinositol-anchor of the frans-sialidase from Trypanosoma cruzi metacyclic trypomastigote forms, Mol. Biochem. Parasitol., 97 (1998) 123-131. 

M. J. M. Alves and W. Colli, Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures, in B. A. Burleigh and D. Soldati-Favre, (Eds.), Molecular Mechanisms of Parasite Invasion, 47 pp. 58-96. 

S. Schenkman, M. A. J. Ferguson, N. Heise, M. L. de Almeida, R. A. Mortara, andN. Yoshida, Mucinlike glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi, Mol. Biochem. Parasitol., 59 (1993) 293-303. 

C. A. Buscaglia, V. A. Campo, A. C. C. Frasch, and J. M. Di Noia, Trypanosoma cruzi surface mucins host-dependent coat diversity, Nat. Rev. Microbiol, 4 (2006) 229-236 A. C. C. Frasch, Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi, Parasitol. Today, 16 (2000) 282-286. 

S. Schenkman and M. Jiang, G.W. Hart and V. Nussenzweig. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells, Cell, 65 (1991) 1117-1125. 

V. M. Mendoza, R. Agusti, C. Gallo-Rodriguez, and R. M. de Lederkremer, Synthesis of the O-linked pentasaccharide in glycoproteins of Trypanosoma cruzi and selective sialylation by recombinant frans-sialidase, Carbohydr. Res., 341 (2006) 1488-1497. 

M. Chuenkova and M. E. S. Pereira, Trypanosoma cruzi trans-sialidase enhancement of virulence in a murine model of Chagas disease, J. Exp. Med., 181 (1995) 1693-1703. 

R. Agusti, M. E. Giorgi, and R. M. de Lederkremer, The trans-sialidase from Trypanosoma cruzi efficiently transfers alpha-(2—>3)-linked N-glycolylneuraminic acid to terminal beta-galactosyl units,... 

M. L. Cremona, O. Campetella, D. O. Sanchez, and A. C. C. Frasch, Enzymically inactive members of the trans-sialidase family from Trypanosoma cruzi display beta-galactose binding activity, Glycobiology, 9 (1999) 581-587. 

A. Buschiazzo, M. F. Amaya, M. L. Cremona, A. C. C. Frasch, and P. M. Alzari, The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis, Mol. Cell,... 

S. Buchini, A. Buschiazzo, and S. G. Withers, A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors, Angew. Chem. Ini. Ed., 47 (2008) 2700-2703. 

A. R. Todeschini, W. B. Dias, M. F. Girard, J. M. Wieruszeski, L. Mendonga-Previato, and J. O. Previato, Enzymatically inactive trans-sialidase from Trypanosoma cruzi binds sialyl and beta-galactopyranosyl residues in a sequential ordered mechanism, J. Biol. Chem., 279 (2004) 5323-5328. 

P. Scudder, J. P. Doom, M. Chenkova, I. D. Manger, and M. E. S. Pereira, Enzymatic characterization of beta-D-galactoside alpha 2,3-trans-sialidase from Trypanosoma cruzi, J. Biol. Chem., 268 (1993) 9886-9891. 

M. Ribeirao, V. L. Pereira-Chioccola, D. Eichinger, M. M. Rodrigues, and S. Schenkman, Temperature differences for frans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase, Glycobiology, 1 (1997) 1237-1246. 

J. A. Harrison, K. P. Kartha, W. B. Turnbull, S. L. Scheuerl, J. H. Naismith, S. Schenkman, and R. A. Field, Hydrolase and sialyltransferase activities of trypanosoma cruzi trans-sialidase towards NeuAc-alpha-2,3-gal-Gal-beta-0-PNP, Bioorg. Med. Chem. Lett., 11 (2001) 141-144. 

S. Singh, M. Scigelova, M. L. Hallberg, O. W. Howarth, D. H. G. Crout, and S. Schenkman, Synthesis of sialyloligosaccharides using the trans-sialidase from Trypanosoma cruzi novel branched and di-sialylated products from digalactoside acceptors, Chem. Commun., 12 (2000) 1013-1014. 

B. Neubacher, D. Schmidt, P. Ziegelmuller, and J. Thiem, Preparation of sialylated oligosaccharides employing recombinant trans-sialidase from Trypanosoma cruzi, Org. Biomol. Chem., 3 (2005) 1551-1556. 

K. B. Lee and Y. C. Lee, Transfer of modified sialic acids by Trypanosoma cruzi trans-sialidase for attachment of functional groups to oligosaccharide, Anal. Biochem., 216 (1994) 358—364. 

M. Engstler, R. Schauer, M. A. Ferrero-Garcia, A. J. Parodi, T. Storz-Eckerlin, A. Vasella, C. Witzig, and X. Zhu, N-(4-Nitrophenyl)oxamic Acid and Related N-Acylanilines Are Non-competitive Inhibitors of vibrio cholerae sialidase but do not inhibit trypanosoma cruzi or trypanosoma brucei trans-sialidases, Helv. Chim. Acta., 77 (1994) 1166-1174. 

M. G. Risso, G. B. Garbarino, E. Mocetti, O. Campetella, S. M. Gonzalez Cappa, C. A. Buscaglia, and M. S. Leguizamon, Differential expression of a virulence factor, the trans-sialidase, by the main Trypanosoma cruzi phylogenetic lineages, J. Infect. Dis., 189 (2004) 2250-2259. 

J. Mucci, A. Hidalgo, E. Mocetti, P. F. Argibay, M. S. Leguizamon, and O. Campetella, Thymocyte depletion in Trypanosoma cruzi infection is mediated by frans-sialidase-induced apoptosis on nurse cells complex, Proc. Natl. Acad. Sci. USA, 99 (2002) 3896-3901. 

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