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Sialic acid binding domain

Figure 5.24 Space-filling model (green) of the sialic acid binding domain of hemagglutinin with a bound inhibitor (red) Illustrating the different binding grooves. The sialic acid moiety of the Inhibitor binds in the central groove. A large hydrophobic substituent, Ri, at the Cz position of sialic acid binds in a hydrophobic channel that runs from the central groove to the bottom of the domain. (Adapted from S.J. Watowich et al.. Structure 2 719-731, 1994.)... Figure 5.24 Space-filling model (green) of the sialic acid binding domain of hemagglutinin with a bound inhibitor (red) Illustrating the different binding grooves. The sialic acid moiety of the Inhibitor binds in the central groove. A large hydrophobic substituent, Ri, at the Cz position of sialic acid binds in a hydrophobic channel that runs from the central groove to the bottom of the domain. (Adapted from S.J. Watowich et al.. Structure 2 719-731, 1994.)...
Jin, L. McLean, P. A. Neel, B. G. Wortis, H. H., Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling. JExp Medim, 195, (9), 1199-205. [Pg.14]

Dormitzer PR, Sun ZY, Wagner G, Harrison SC (2002) The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. EMBO J... [Pg.27]

Human siglecs Number of Ig domains Number of cytoplasm ic tyrosine motifs Sialic-acid- binding specificity Expression... [Pg.2471]

Nath D., van der Merwe P. A., Kelm S., Bradfield P. and Crocker P. R. (1995) The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22, J. Biol. Chem. 270 26184-26191. [Pg.1056]

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See also in sourсe #XX -- [ Pg.80 , Pg.81 ]



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