Sharpe, Mitchell

In some animals, consumption of a phytoestrogen-rich diet can cause temporary infertility and reproductive system disorders (Irvine, 1999). In humans, lower testosterone levels and a decline in human semen quality over the past century have been luiked to increased exposure to environmental endocrine disrupters (EDCs) (Sharpe and Skakkebaek, 1993). Furthermore, cases of sexual impotence have been reported in males exposed to synthetic estrogens in the pharmaceutical industry (Mattison et al., 1990). If this might be the case, the fetal-prepubertal period and Sertoli cell development would be of critical importance (Sharpe and Skakkebaek, 1993). However, an adverse effect of phytoestrogens on male fertility has yet to be proven. Recent work (Mitchell et al., 2001) addressing this point led to the conclusion that up to 40 mg/day of isoflavones over a two-month period had no effects on gonadotrophin and... 

Pilotte NS, Mitchell WM, Sharpe LG, De Souza EB, Dax EM. (1991). Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain. Synapse. 9(2) 111-20. 

Despite the importance of hydrodemetallation reactions and their intimate relationship to HDS, HDN, and HDO, relatively little is understood of the underlying fundamentals. Only recently have model compounds been used to explore the intrinsic reactivity of metal-bearing compounds and the nature of the catalytic sites responsible for these reactions. This is in sharp contrast to the wealth of model compound information existing in the literature on HDS (Gates et al., 1979 Mitchell, 1980 Vrinat, 1983), HDN (Katzer and Sivasubramanian, 1979 Satterfield and Yang, 1984 Ho, 1988) and HDO (Furimsky, 1983 Satterfield and Yang, 1983). 

Sharpe JC, Mitchell JS, Lin L, Sedoglavich H, Blaikie RJ (2008) Gold nanohole array substrates as immunobiosensors. Anal Chem 80 2244-2249... 

Levine AS, Sharp HL, Mitchell J, Krivit W, Nesbit ME. Combination therapy with 6-mercaptopurine (NSC-755) and allopurinol (NSC-1390) during induction and maintenance of remission of acute leukaemia in children. Cancer ChemotherRep (1969) 53, 53-7,... 

Chou En-lai (third from right) meets Roy Errington (second from right) at the Canadian Trade Fair in Peking (August, 1972). Standing behind the post is Mitchell Sharpe, Minister of External Affairs. 

References H. S. Rosenkranz and H. S. Carr, unpublished results M. H. Billimoria (Imperial Tobacco), personal communication . M. Kiggins (Rhodia Inc., Hess and Clark Division), personal communication P. A. Watkins and J. C. Topham (ICI, Pharmaceuticals Division), personal communication H. R. Skeggs (Merck Sharp Dohme), personal communication D. Weinstein (Hoffmann-La Roche, Inc.), personal communication T. Wagner-Jauregg and J. Fischer (Siegfried, AG), personal communication T. G. Mitchell (Group Research and Development Centre, British-American Tobacco Co., Ltd), personal communication D. J. Brusick (Litton-Bionetics), personal communication J. P. Brown (Dynapol), personal communication J. E. Heinze (Armour-Dial, Inc.), personal cmnmunication. 

Lipton, Michael F., 101 Lugar, Charles, 133 Martin, Michael T., 31 Matsuoka, Richard T., 31 Mauragis, Michael A., 101 McGrane, Paul, 89 Mitchell, David, 133 Moore, David, 89 Morton, Howard E., 45 Nafissi, Mehdi, ix Palmer, John R., 101 Petousis, Nikolaos H., 1 Prince, Anthony, 89 Sarma, Keshab, 89 Schwartz, Theresa M., 101 Sharp, Matthew J., 31 Strouse, ErinE., 133 Veley, Michael F., 101 Walker, Keith, 89 Wittenberger, Steven J., 45 Yee, Calvin, 89 Zhang, Ji, 45 Zhou, Xiaoming, 31 Zimmerman, David C., 101... 

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