Severe Combined Immune Deficient Mouse Model

Severe Combined Immune Deficient Mouse Model 

Cellular reservoirs and anatomical sanctuary sites, such as the CNS, hamper HTV-l treatment and allow HTV-l to persist. To these ends, the SCID mouse model was modified to allow spread of HTV-1 infection betw een human MDM in mouse brain tissue behind an intact BBB. This model permitted comparative assessment of different anti-retroviral drugs by measurements of viral load and numbers of infected human macrophages (Limoges et al., 2000 Limoges et al., 2001). New drug delivery systems across the BBB and novel neuropro tec five therapeutics are under investigation (Persidsky et al., 2001 Dou et al., 2003 Dou et al., 2005). 

Elimination of infected macrophages in the lymphocyte reconstituted SCID mouse HTVE model was accompanied by diminished infiltration of CD8+ lymphocytes in the 

Studies performed over a period of tw o decades indicate that HTV-associated cognidve impairment is a chronic neuro-inflammatory concUdon. Mi us producdve infecdon of brain MP 

HIV-1 brain infection in post-HAART era is charac-teiized by 

Introduction of HAART resulted in more severe neuro-cognitive impairment in HIV-1 infected patients 

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Severe Combined Immune Deficient Mouse Model... 

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