Sesterstatins

From the Maldives Black marine sponge Hyrtios erectci, several cytotoxic sesterterpenes were isolated, such as the penytacyclic sesterterpenes designated sesterstatins [125-127] and puupehenone, Fig. (18) with a quinone-methide system [128], Three novel cytotoxic nor-sesterterpenes, rhopaloic acid A, Fig. (19), B and C, were recently isolated from the sponge Rhopciloeides sp. 

Hainan Is., China) contained 12o -0-acetylhyrtiolide (197) [103]. A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (198), was isolated from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses with HRMS and high-field 2-D NMR spec-... 

The novel sesterterpene salmahyrtisol A and three other new sca-larane-type sesterterpenes (salmahyrtisol, 3-acetyl sesterstatin 1, and 19-acetyl sesterstatin 3), isolated from the Red Sea sponge Hyrtios erecta, have significant cytotoxicity against human lung carcinoma, human colon carcinoma, and murine lukemia. Halorosellinic acid, an... 

Pettit, G.R., Tan, R and Cichaez, Z.A. (2005) Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian ocean sponge Hyrtios erecta.J. Nat Prod., 68,1253-1255. 

R. K. (1998a) Antineoplastic agents. 386. Isolation of sesterstatins 1-3 from the marine sponge Hyrtios erecta. J. Nat. Prod., 61,13-16. 

S., Pettit, R.K., and Chapuis, J.-C. (1998b) Antineoplastic agents. 397. Isolation and stmcture of sesterstatins 4 and 5 from Hyrtios erecta (The Republic of Maldives). Bioorg. Med. Chem. Lett., 8, 2093-2098. 

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