Serotonin regulation

FIGURE 11 — 18. Serotonin regulation of dopamine release from nigrostriatal dopamine neurons, part 1. Here, dopamine is being freely released from its axon terminal in the striatum because there is no serotonin causing any inhibition of dopamine release. 

My general knowledge about serotonin regulation of dopamine was enhanced. ... 

Laplante P, Diorio J, Meaney MJ. Serotonin regulates hippocampal glucocorticoid receptor expression via a 5-HT7 receptor. Brain Res Dev Brain Res 2002 139 199-203. 

Catecholamines and serotonin regulate physiological events at the cellular level by interaction with families of cell-surface receptors. Adrenergic receptors, classified as tti (subtypes aia,b,d)) 2 (subtypes pi, p2> and p3 subcate-... 

Serotonin plays multiple roles in the nervous system, including neurotransmission. It is a precursor to melatonin, which is involved in the regulation of sleepiness and wakefulness. In the intestine, serotonin regulates intestinal peristalsis. Serotonin is also a potent vasoconstrictor, which helps regulate blood pressure. 

Melatonin. Melatonin (A/-acetyl-5-metlioxytryptaniine) [73-31-4] C 2H gN2O2(250) is secreted from the pineal gland and retina during dark periods of the vertebrate circadian rhythm (65). Melatonin regulates biological rhythms and neuroendocrine function and is formed from serotonin (5-HT). 

Certain amino acids and their derivatives, although not found in proteins, nonetheless are biochemically important. A few of the more notable examples are shown in Figure 4.5. y-Aminobutyric acid, or GABA, is produced by the decarboxylation of glutamic acid and is a potent neurotransmitter. Histamine, which is synthesized by decarboxylation of histidine, and serotonin, which is derived from tryptophan, similarly function as neurotransmitters and regulators. /3-Alanine is found in nature in the peptides carnosine and anserine and is a component of pantothenic acid (a vitamin), which is a part of coenzyme A. Epinephrine (also known as adrenaline), derived from tyrosine, is an important hormone. Penicillamine is a constituent of the penicillin antibiotics. Ornithine, betaine, homocysteine, and homoserine are important metabolic intermediates. Citrulline is the immediate precursor of arginine. 

HT3 receptor. 5-Hydroxytryptamine receptor a receptor for serotonin (a neurotransmitter), which activates a variety of second messenger signaling systems and through them indirectly regulates the function of ion channels. 

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Schuldiner, S (1998) Vesicular neurotransmitter transporters. In Neurotransmitter Transporters Structure, Function, and Regulation (Ed. Reith, MEA), Humana Press, Totowa, NJ, pp. 215-240. Stanford, SC (1995) Central noradrenergic neurones and stress. Pharmac. Ther. 68 297-342. Stanford, SC (1999) SSRI-induced changes in catecholaminergic transmission. In Selective Serotonin Reuptake Inhibitors (SSRIs) Past, Present and Future (Ed. Stanford, SC), RG Landes Co., Austin, TX, pp. 147-170. 

Blakely, RD, Ramamoorthy, S, Schroeter, S, Qian, Y, Apparsundaram, S, Galli, A and DeFelice, LJ (1998) Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins. Biol. Psychiatry 44 169-178. 

Boadle-Biber, MC (1993) Regulation of serotonin S5mthesis. Prog. Biophys. Molec. Biol. 60 1-15. Curzon, G, Gibson, EL and Oluyomi, AO (1997) Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol. Sci. 18 21-25. Gaddum, JH and Picarelli, ZP (1957) Two kinds of tr5 ptamine receptor. Brit. J. Pharmacol. 12 323-328. (Reproduced in Brit. J. Pharmacol. 120 (Suppl) 134-139.)... 

Battaglia, G. Shannon, M. and Titeler. M. Guanyl nucleotide and divalent cation regulation of cortical S2 serotonin receptors. J Neurochem 43 1213-1219, 1984. 

Conn, P.J., and Sanders-Bush, E. Central serotonin receptors Effector systems, physiological roles and regulation. Psychopharmacology 92 267-277, 1987. 

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