Sleep-wake regulation serotonin

Melatonin (fig. 10) is a hormone produced from serotonin in the pineal gland, which is embedded within the brain. It is released into the brain and general blood circulation and is involved in the regulation of the sleep-wake cycle and other circadian biological clock processes. 

Nature Melatonin is a serotonin derivative produced mainly in the pineal gland. It is thought to regulate sleep-wake cycles, and its release coincides with darkness (9 pm to... 

Devise a synthesis of melatonin, the mammalian hormone involved in regulating the sleep-wake cycle, from the neurotransmitter serotonin, alcohols, and any needed organic and inorganic reagents. 

Although many questions remain about the complicated role of serotonin and its receptors in regulating sleep and waking, recent neurochemical, electrophysiological, and neuropharmacological studies have revealed much detailed information about this process. 

Melatonin, a hormone secreted by the pineal gland that regulates circadian rhythms, including wake-sleep cycles, is biosynthesized by a process in which the first step is an enzyme-catalyzed transfer of the acetyl group from sulfur of acetyl coenzyme A to the —NH2 group of serotonin. 

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