Serotonin 5-HT1D receptor

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Xie, Z., Lee, S. P., O Dowd, B. F., and George, S. R. (1999) Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when coexpressed. FEBS Lett. 456, 63-67. 

Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR. Human serotonin ID receptor is encoded by a subfamily of two distinct genes 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci USA 1992 89 3630-3634. 

Initial attention in the serotonin field was focused on the first three receptor populations to be identified 5-HT1A, 5-HT1B, and 5-HT2 receptors. However, once the presence of 5-HT1B receptors in the human brain was questioned, interest in this population temporarily subsided. With the discovery of a new population of 5-HTj receptors, 5-HT1D receptors, came the realization of a structural and functional similarity between 5-HT1B and 5-HT1D receptors. On the basis of... 

Glennon RA, Westkaemper RB. 5-HT1D receptors a serotonin receptor population for the 1990s. Drag News Perspect 1993 6 390-405. 

Schoeffier P, Hoyer D. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HTlc and 5-HT1D receptors. Eur J Pharmacol 1991 196 213-216. 

Cattaneo MG, Palazzi E, Bondiolotti G, Vicentini LM. 5-HT1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma. Eur J Pharmacol 1994 268 425-430. 

Choi DS, Birraux G, Launay JM, Maroteaux L. The human serotonin 5-HT2B receptor pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS Lett 1994 352 393-399. 

Sumatriptan is a serotonin agonist, acting at 5-HT1D receptors. 

Levy FO, Gudermann T, Perez-Reyes E, Bimbaumer M, Kaumann AJ, Bim-baumer L. Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. J Biol Chem 1992 267 7553-7562. 

Hamblin MW, McGuffin RW, Metcalf MA, Dorsa DM, Merchant KM. Distinct 5-HT1B and 5-HT1D serotonin receptors in rat structural and pharmacological comparison of the two cloned receptors. Mol Cell Neurosci 1992 3 578-587. 

Maenhaut C, Van Sande J, Massart C, et al. The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor. Biochem Biophys Res Commun 1991 180 1460-1468. 

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Prisinzano TP, Law H, Slassi A, MaClean N, Demchyshyn L, Glennon RA. QSAR studies on 2-benzylimidazoline analogs as h5-HT1D/1B serotonin receptor ligands. Med Chem Res 2001 10 309-317. 

Prisinzano T, Dukat M, Law H, et al. 2-(Anilino)imidazolines and 2-(benzyl)-imidazoline derivatives as /z5-HT1D serotonin receptor ligands. Bioorg Med Chem Lett 2004 14 4697-4699. 

Bondarev M, Iwamura T, Hynd D, et al. Aryloxyethylamines as h5-HT1D serotonin receptor ligands. Med Chem Res 1998 8 333-342. 

Maura G, Raiteri M. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. J Neurochem 1996 66 203-209. 

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Hamblin MW, Metcalf MA. Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol 1991 40 143-148. 

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