5-HT1d receptor

Hartig, P. R., Hoyer, D., Humphrey, P. P. A. and Martin, G. Alignment of receptor nomenclature with the human genome classification of 5-HT1B and 5-HT1D receptor subtypes. Trends Pharmacol. Sci. 17 103-105,1996. 

Xie, Z., Lee, S. P., O Dowd, B. F., and George, S. R. (1999) Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when coexpressed. FEBS Lett. 456, 63-67. 

Wurch T, Palmier C, Colpaert FC, Pauwels PJ. Sequence and functional analysis of cloned guinea pig and rat serotonin 5-HT1D receptors common pharmacological features within the 5-HT1D receptor subfamily. J Neurochem 1997 68 410-418. 

Initial attention in the serotonin field was focused on the first three receptor populations to be identified 5-HT1A, 5-HT1B, and 5-HT2 receptors. However, once the presence of 5-HT1B receptors in the human brain was questioned, interest in this population temporarily subsided. With the discovery of a new population of 5-HTj receptors, 5-HT1D receptors, came the realization of a structural and functional similarity between 5-HT1B and 5-HT1D receptors. On the basis of... 

Glennon RA, Westkaemper RB. 5-HT1D receptors a serotonin receptor population for the 1990s. Drag News Perspect 1993 6 390-405. 

Schoeffier P, Hoyer D. Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HTlc and 5-HT1D receptors. Eur J Pharmacol 1991 196 213-216. 

Like the other 5-Hrl receptors, the major signaling pathway of the 5-HT1D receptor is to the inhibition of AC through pertussis toxin-sensitive G proteins in the substantia nigra (153), in MDCK cells (154), and in transfected C6 glioma and NIH-3T3 fibroblast cells (116,134,155,156). 

Cattaneo MG, Palazzi E, Bondiolotti G, Vicentini LM. 5-HT1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma. Eur J Pharmacol 1994 268 425-430. 

Pineyro G, de Montigny C, Blier P. 5-HT1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology 1995 13 249-260. 

Akin D, Gurdal H. Involvement of 5-HTm and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery. Br J Pharmacol 2002 136 177-182. 

Hartig PR, Branchek TA, Weinshank RL. A subfamily of 5-HT1D receptor genes. Trends Pharmacol Sci 1992 13 152-159. 

Hoyer D, Schoeffter P. 5-HT1D receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra. Eur J Pharmacol 1988 147 145-147. 

Schoeffter P, Bobimac I. 5-Hydroxytryptamine 5-HT1D receptors mediating inhibition of cyclic AMP accumulation in Madin-Darby canine kidney (MDCK) cells. Naunyn Schmiedebergs Arch Pharmacol 1995 352 256-262. 

Van Sande J, Allgeier A, Massart C, et al. The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells. Eur J Pharmacol 1993 247 177-184. 

Pauwels PJ, Wurch T, Palmier C, Colpaert FC. Promotion of cell growth by stimulation of cloned human 5-HTm receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol 1996 354 136-144. 

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