Nausea/vomiting serotonin receptor antagonists

Intrathecal morphine is often used in women undergoing cesarean delivery to enhance postoperative analgesia, but it is generally associated with significant adverse reactions, such as pruritus, nausea, and vomiting. A systematic review and meta-analysis of nine randomized controlled trials in 1152 patients has shown that the combination of morphine with serotonin receptor antagonists was associated with reduced severity of pruritus and a lower frequency of nausea and vomiting [133 ]. 

George RB, Allen TK, Habib AS. Serotonin receptor antagonists for the prevention and treatment of pruritus, nausea, and vomiting in women undergoing cesarean delivery with intrathecal morphine a systematic review and meta-analysis. Anesth Analg 2009 109 174-82. 

HT receptor antagonists In a systematic review of nine randomized controlled studies, serotonin receptor antagonists significantly reduced the severity of pruritus and the need for treatment, but did not affect its incidence the incidence of postoperative nausea and vomiting was reduced [IW ]. 

Ondansetron is a 5HT3 antagonist, blocking serotonin receptors in the central nervous system and the gastrointestinal tract. It is useful in the management of postoperative nausea and vomiting associated with cytotoxics. 

Odansetron is an antagonist of the serotonin receptor 5-HT3. Its main use is in combating the nausea and vomiting which frequently accompanies treatment with anti-cancer chemotherapy. In one short-term, 4-week placebo-controlled trial involving 26 patients with severe BN, odansetron 24 mg daily halved the frequency of binging and vomiting (Faris et al. 2000). Two other small clinical trials support the use of odansetron in BN (Fung and Ferrill 2001). 

Indications Prevention of nausea and vomiting Category 5-HT3 antagonist Serotonin type 3 receptor antagonist Half-life 7.3 hours... 

Ondansetron Alcohol Ondansetron is a serotonin 5-HT3 receptor antagonist, with low affinity for al-adrenergic, 5-HTiB, 5-HTiC, and J-opioid receptors [251]. It is used primarily to treat nausea and vomiting (antiemetic) following chemotherapy. 

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