Serotonergic neurotransmission function

Hariri, A. R. Weinberger, D. R. (2003). Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes Brain Behav., 2(6), 341-9. 

Serotonergic neurotransmission in the central nervous system controls a wide variety of functions such as blood pressure, emotional behavior, endocrine secretion, perception of pain, and sleep. It is possible that the decrease in neuronal 5-HT and the consequent changes in its receptors, particularly S-HTj, may cause hypertension in vitamin Bg deficiency. This was investigated in vitamin Bg-deficient rats after they had developed peak hypertension by examining the effects of various 5HT, agonists. They all had an acute hypotensive effect in these rats. 

The activity of 5-HT in the synapse is terminated primarily by its re-uptake into serotonergic terminals 234 Acute and chronic regulation of serotonin transporter function provides means for altering synaptic 5-HT concentrations and neurotransmission 236... 

Anderson, E. G., and Proudfit, H. K. (1981) The functional role of the bulbospinal serotonergic nervous system. In Serotonin, Neurotransmission and Behavior, edited by B. L. Jacobs and A. Gelperin, pp. 307-338. MIT Press. Cambridge. 

Serotonin and catecholamine functions in the central nervous system are both diverse and complex, and direct assessment of central neurotransmitters by cfinical laboratory methods is currently limited. The effects, however, of central serotonergic, dopaminergic, and serotonergic systems on metabolic and hormonal function are routinely measured in the clinical laboratory, and many of the therapeutic and illicit drugs that modulate central monoamine neurotransmission are monitored by laboratory techniques in a wide range of clinical settings. 

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