Seroquel schizophrenia

Quetiapine (Seroquel). Quetiapine is the fourth of the atypical antipsychotics introduced in the United States. It is effective in both positive and negative symptoms of schizophrenia within a dose range of 150 to 750mg/day in two divided... 

Arvanitis LA, Miller BG Multiple fixed doses of Seroquel (quetiapine) in patients with acute exacerbation of schizophrenia a comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group. Biol Psychiatry 42 233-246, 1997... 

Gefvert, O., Bergstrom, M., Langstrom, B., et at. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology 135, 119-126, 1998. 

Serzone (nefazodone) for depression and Seroquel (quetiapine) for schizophrenia... 

In 2005, an NIMH multisite study called CATIE compared the older neuroleptic perphenazine (Trilafon) and atypical neuroleptics olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), and zipra-sidone (Geodon Lieberman et al., 2005a see also Nasrallah, 2007 Rosenheck et al., 2006 Weiden, 2007a). Phase I involved 1,460 patients diagnosed with schizophrenia initially randomly assigned in a doubleblind study to one of the five neuroleptics. The study lasted 18 months, with safety and tolerability outcomes evaluated at 1, 3, 6, 9, 12, 15, and 18 months. 

Copolov DL, Link CG, Kowalcyk B. A multicentre, double-blind, randomized comparison of quetiapine (ICI 204,636, Seroquel ) and haloperidol in schizophrenia. Psychol Med 2000 30(1) 95-105. 

Small JG, Hirsch SR, Arvanitis LA, Miller BG, Link CG. Quetiapine in patients with schizophrenia. A high- and low-dose double-blind comparison with placebo. Seroquel Study Group. Arch Gen Psychiatry 1997 54(6) 549-57. 

Trade name Seroquel (AstraZeneca) Indications Psychotic disorders, schizophrenia Category Antipsychotic Mood stabilizer Half-life 6 hours... 

Seroquel Quetiapine fumarate Schizophrenia 3.0 9 Enbrel Etanercept Tumor necrosis factor for rheumatoid arthritis 4.5 18.4... 

At present there are several medications that have been approved that involve the neurochemical serotonin. The first two medications are clozapine and risperidone and the two newer medications are Seroquel and Zyprexa. To date, these medications have been termed the atypical antipsychotic medications, because they are effective in reducing symptoms of schizophrenia and are less likely to cause extrapyramidal side effects than the other antipsychotic medications (Karper Krystal, 1996). 

RISPERDAL), for example, is a potent S-HT and receptor antagonist. Low doses of risperidone have been reported to attenuate negative symptoms of schizophrenia with a low incidence of extrapyramidal side effects. Extrapyramidal effects are commonly seen, however, with doses of risperidone in excess of 6 mg/day. Other atypical antipsychotic agents—quetiapine (seroquel) and olanzapine (zyprexa)—act on multiple receptors, but their antipsychotic properties are thought to be due to antagonism of DA and 5-HT. 

Which assessment data indicates the atypical antipsychotic quetiapine (Seroquel) is effective for the client diagnosed with paranoid schizophrenia ... 

Quetiapine, marketed as Seroquel, is a heavily prescribed antipsychotic drug used in the treatment of schizophrenia and bipolar disorder. Convert the following representation into a skeletal structure, and give the molecular formula of quetiapine. 

---