Seroquel

Casey DE (1996). Seroquel (quetiapine). Preclinical and clinical findings of a new atypical antipsychotic. Expert Opin Invest Drugs 5, 939-57. 

Sailer CF, SalamaAI (1993). Seroquel biochemical profile of a potential atypical antipsychotic. Psychopharmacology 112, 285-8. 

Quetiapine Seroquel Tablet 25,50,100,200, 300, 400 mg 50-800 mj day in divided doses or once daily when stabilized... 

Quetiapine (Seroquel). Another atypical antipsychotic, quetiapine has also been approved by the FDA for the treatment of acute mania. It is usually administered twice daily at doses of 150-750mg/day. Like its counterparts, quetiapine is a well-tolerated medication. Its common side effects are drowsiness, dizziness, and headache. It causes less weight gain than olanzapine or clozapine but more than ziprasidone or aripiprazole. Quetiapine also does not cause agranulocytosis nor does it increase the risk of seizures. It can occasionally cause mild changes in liver function tests, but these usually return to normal even if the patient continues taking quetiapine. 

Quetiapine (Seroquel). Quetiapine is the fourth of the atypical antipsychotics introduced in the United States. It is effective in both positive and negative symptoms of schizophrenia within a dose range of 150 to 750mg/day in two divided... 

Atypical antipsychotics may be helpful in managing the delusions and agitated behavior that can accompany dementia. These medications, include risperidone (Risperdal), quetiapine (Seroquel), ziprasidone (Geodon), aripiprazole (Abilify), and olanzapine (Zyprexa). All antipsychotics, typical and atypical, appear to increase the risk of death in patients with dementia and psychosis. This appears as a warning in the package inserts of the newer drugs. A prudent approach is to discuss this risk with the caregiver, use the lowest effective dose, and monitor for effectiveness. 

Other medications that can be considered are zolpidem (Ambien), the benzodiazepine temazepam (Restoril), quetiapine (Seroquel), and chloral hydrate. 

Among these choices, bnspirone is preferred if the patient is also experiencing anxiety. If the patient is depressed and agitated, a SSRI should be tried first. Second line choices inclnde carbamazepine (Tegretol) or one of the atypical antipsychot-ics—ziprasidone (Geodon), risperidone (Risperdal), olanzapine (Zyprexa), quetiap-ine (Seroquel), or aripiprazole (Abilify) can be tried. If psychotic symptoms are present, one of the atypical antipsychotics should be tried first. 

Top 11-20 brands (all figures in billion) Ogastro/Prevacid (Takeda), 3.5 Effexor (Wyeth), 3.5 Procrit/Eprex (Johnson Johnson), 3.3 MabThera/Rituxan (Roche), 3.3 Zoloft (Pfizer), 3.3 Fosamax (Merck), 3.2 Singulair (Merck), 3 Cozaar+Hyzaar (Merck), 3 Seroquel (AstraZeneca), 2.8 Remicade (Johnson Johnson), 2.5 Lovenox (Sanofi-Aventis), 2.7. 

Zyrtec 2.2 Depakote 1.1 Aciphex 2.4 Levaquin — Seroquel 2.9 Allegra 1.7... 

Arvanitis LA, Miller BG Multiple fixed doses of Seroquel (quetiapine) in patients with acute exacerbation of schizophrenia a comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group. Biol Psychiatry 42 233-246, 1997... 

Gefvert, O., Bergstrom, M., Langstrom, B., et at. Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology 135, 119-126, 1998. 

Receptor-Binding Studies. Quetiapine (Seroquel) is also a dibenzothiazepine derivative produced by altering the structure of clozapine. This agent has an affinity for multiple brain receptors, a low propensity to evoke EPS in preclinical tests considered predictive of antipsychotic activity, and does not produce sustained plasma prolactin levels. 

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