Serological antigen-antibody agglutination

In most patients, serologic evidence remains the primary method in the diagnosis of histoplasmosis. Results obtained from complement fixation, immunodiffusion, and latex antigen agglutination antibody tests are used... 

Nevertheless the phenomena of agglutination and serological precipitation are striking ones, and it is of interest to see whether they can be explained by the same forces that produce specific combination of antibody and antigen, or whether some additional explanation must be invoked. In suggesting that the first of these alternatives is correct, and that agglutination and precipitation result fi-om multivalency of the antibody, Marrack [6] adduced various experimental observations in support of his proposal. Further support for the framework theory was provided by the work of Heidelberger and Kendall [9]. 

Tube agglutination test Serologic test that measures antibody titers by comparing various dilutions of the patient s serum against known quantities of an antigen. 

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