Sensitivity maximizer

Caffeine sensitivity Maximal Voltage gated release Sensitivity to voltage Ca2+ stores ref... 

Figure 7.17 shows this function graphically (cf Section 6.2.2). Here the time constant of the exponential temperature rise is r = Csc Rth2> and the final temperature of the sample container is Tfin = Tp + 0i l th2- Otie can clearly see the influence of the thermal resistance Rthi on the time constant r and on the sensitivity (maximal AT = Tfi — Tp) of the calorimeter... 

Historically, the first and most important capacitance method is the vibrating capacitor approach implemented by Lord Kelvin in 1897. In this technique (now called the Kelvin probe), the reference plate moves relative to the sample surface at some constant frequency and tlie capacitance changes as tlie interelectrode separation changes. An AC current thus flows in the external circuit. Upon reduction of the electric field to zero, the AC current is also reduced to zero. Originally, Kelvin detected the zero point manually using his quadrant electrometer. Nowadays, there are many elegant and sensitive versions of this technique. A piezoceramic foil can be used to vibrate the reference plate. To minimize noise and maximize sensitivity, a phase-locked... 

Sensitivity Sensitivity in flame atomic emission is strongly influenced by the temperature of the excitation source and the composition of the sample matrix. Normally, sensitivity is optimized by aspirating a standard solution and adjusting the flame s composition and the height from which emission is monitored until the emission intensity is maximized. Chemical interferences, when present, decrease the sensitivity of the analysis. With plasma emission, sensitivity is less influenced by the sample matrix. In some cases, for example, a plasma calibration curve prepared using standards in a matrix of distilled water can be used for samples with more complex matrices. 

Ferroelectric Ceramic—Polymer Composites. The motivation for the development of composite ferroelectric materials arose from the need for a combination of desirable properties that often caimot be obtained in single-phase materials. For example, in an electromechanical transducer, the piezoelectric sensitivity might be maximized and the density minimized to obtain a good acoustic matching with water, and the transducer made mechanically flexible to conform to a curved surface (see COMPOSITE MATERIALS, CERAMiC-MATRix). 

Sensitization results are based on a human maximization test (103) usiag a petrolatum vehicle. The effect is expressed as the number of paneHsts responding over the total number of paneHsts tested and was 0/25 except for spearmint (0/32). That is, at the dose iadicated, the oils werenot irritating when tested ia a 48-h closed patch test ia humans. 

In the analysis of trace elements or thin films on substrate using electrons, however, one finds that the MDL, may be increased by choosing Eq such that Uis just greater than 1. The reason for this is that the k factor, which is the ratio of the intensity from the sample to that from the standard, increases as Uapproaches 1 for thin films. Thus, by maximizing the k factor, the sensitivity is increased. For bulk sample analysis, however, the k factor will usually be a maximum ax. U- 2.5. 

As discussed above, it is desirable to use large, almost grazing angles of incidence in RAIR spectroscopy in order to maximize the sensitivity of the technique to ultra-thin films. Using such large angles of incidence usually requires the substrates to be at least a few centimeters in length. This severely limits the spatial... 

Because all measurement methods and instruments are sensitive to the velocity profile, the choice of the measurement cross-section is of vital importance. In most ventilation systems there is seldom enough straight duct to allow a fully developed velocity profile to develop, which is the most favorable for flow measurement. Thus, the principle in selecting the measurement cross-section is to find the place where the velocity profile is as near to the fully developed profile as possible. In practice the distance from the nearest source of disturbance upstream is maximized, ensuring that the distance to the nearest downstream disturbance is at least 3 to 5 duct diameters. 

Reduction of aromatic nitro compounds may give products sensitive to air. Moder and Leonard (d5) stressed the importance of rigid exclusion of air during reduction of a nitro compound to a complex air-sensitive diamine in order to maximize the yield. It is quite likely that in these cases the oxidation products will have an adverse influence on catalyst life. 

Allosteric antagonism is characterized by the fact that it attains a maximal value. A sensitive method for the detection of allosteric effects is through studying the kinetics of binding. 

The first idea to consider is the effect of receptor density on sensitivity of a functional system to agonists. Clearly, if quanta of stimulus are delivered to the stimulus-response mechanism of a cell per activated receptor the amount of the total stimulus will be directly proportional to the number of receptors activated. Figure 5.8 shows Gi-protein-mediated responses of melanophores transiently transfected with cDNA for human neuropeptide Y-l receptors. As can be seen from this figure, increasing receptor expression (transfection with increasing concentrations of receptor cDNA) causes an increased potency and maximal response to the neuropeptide Y agonist PYY. 

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