Self-calibrating high-throughput content uniformity measurements

1 Self-calibrating high-throughput content uniformity measurements 

To demonstrate the ability to evaluate inter-sample variations, tablet groups from two different manufacturers in an over-the-counter (OTC) pain relief medication were compared. Pure acetaminophen, aspirin, and caffeine samples are obtained in either tablet form or powder compact and included within the same FOV as the tablets to provide simultaneous reference materials for the tablet samples. The tablets and pure components were arranged as shown in Plate la. This FOV contains 20 tablets and the 

The raw images were dark corrected as described previously, then background corrected using a data cube collected from Spectralon (Labsphere, Inc., North Sutton, 

Plate 1 (a) Key to placement of tablet matrix and pure component reference samples for high-throughput 

2 High-throughput applications Counterfeit screening/quality assurance 

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