High-throughput applications

A more general analysis requires the use of two effective permeability coefficients, one for each pH, each of which would be valid in the respective iso-pH conditions. Since fewer limiting assumptions are made, the more general method may be more suitable for high-throughput applications. We continue to derive the appropriate new model. 

The combination of increased Pe and decreased %R allowed the permeation time to be lowered to 4 h, in comparison to the originally specified time of 15 h [547,550], a considerable improvement for high-throughput applications. The quality of the measurements of the low-permeability molecules did not substantially improve with sink conditions or the reduced assay times. 

The PG models 9.1 and 10.1 show similar trends as indicated by PA, but the effects are somewhat muted. The increase in PG from 0.6% to 1.1% causes the permeabilities of weak bases to decrease and membrane retentions to increase, with many bases showing R > 60%. Many molecules were not detected in the acceptor compartments by UV spectrophotometry after 4 h permeation times (Table 7.7). These properties of the PG system make it less attractive for high-throughput applications than the other two-component models. 

Esposito, A., Gerritsen, H. C. and Wouters, F. S. (2007a). Optimizing frequency-domain fluorescence lifetime sensing for high-throughput applications photon economy and acquisition speed. J. Opt. Soc. Am. 24, 3261-73. 

Utility of 384-Well Plates for High-Throughput Applications... 

Ultrahigh Pressure Nano LC for High-Throughput Applications.364... 

Figure 22 shows a high-throughput application in which high flow rate, a short column with very small particles packings, short and... 

NIR-CI instrumentation is rugged and flexible, suitable for both the laboratory and manufacturing environment. Therefore analysis methods developed in the laboratory can often be tailored for implementation near-line or at-line. NIR-CI is also a massively parallel approach to NIR spectroscopy, making the technique well suited for high throughput applications. 

Plastic substrates are now utilized for both nucleic acid and protein microarrays. In particular, plastic microarrays have been introduced for high-throughput applications based upon the microtiter plate which is the standard automation platform. 

High-throughput applications Counterfeit screening/quality assurance... 

Alternatives to two-dimensional electrophoresis are currently under development in these approaches, liquid chromatography or capillary electrophoresis is used for easier automation and capability of high-throughput application. 

Also an increase in volume flow in these reactors is inevitable. Micro structured reactors for high-throughput applications can consist of hundreds of plates all of them have to be of a uniform size with a uniform coating and, of course, should be inexpensive [158], especially as the micro structured plates sometimes will have to be exchanged in case of fouling or deactivation of the coated catalyst. 

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