Drug delivery self-assembled micelles

Bian F, Jia L et al (2009) Self-assembled micelles of N-phthaloylchltosan-g-polyvlnylpyr-rolldone for drug delivery. Carbohydr Polym 76 454 59... 

Multi-functional micelles self-assembled from LDBCs have been developed for intracellular delivery of antitumor drugs. Self-assembled micelles of amphiphilic LDBCs comprised of semi-polyamidoamine-fe-poly(D,L-lactic acid) (PALA) were used to deliver docetaxel (DTX) to MCF-7 cells in vitro. In rat models, the DTX-loaded PALA micelles showed enhanced plasma concentrations of DTX and prolonged drug clearance in comparison to a clinically used... 

Y. Song, L. Zhang, W. Gan, J. Zhou, L. Zhang, Self-assembled micelles based on hydrophobically modified quatemized cellulose for drug delivery. Colloids Surf., B 83 (2011)313-320. 

In 2000, the first example of ELP diblock copolymers for reversible stimulus-responsive self-assembly of nanoparticles was reported and their potential use in controlled delivery and release was suggested [87]. Later, these type of diblock copolypeptides were also covalently crossUnked through disulfide bond formation after self-assembly into micellar nanoparticles. In addition, the encapsulation of l-anilinonaphthalene-8-sulfonic acid, a hydrophobic fluorescent dye that fluoresces in hydrophobic enviromnent, was used to investigate the capacity of the micelle for hydrophobic drugs [88]. Fujita et al. replaced the hydrophilic ELP block by a polyaspartic acid chain (D ). They created a set of block copolymers with varying... 

Recently, biodegradable polymers have been used to fabricate macro- and nanometer scale self-assembled systems such as microspheres (MSs), nanospheres (NSs), polymer micelles, nanogels, and polymersomes (Fig. 1). These have attracted growing interest because of their potential utility for drug delivery systems (DDS), tissue engineering, and other applications. To construct these self-assembled systems... 

Polymer micelles are nanometer sized (usually several tens of nanometers) self-assembled particles having a hydrophobic core and hydrophilic outer shell composed of amphiphilic AB- or ABA-type block copolymers, and are utilized as drug delivery vehicles. The first polymer micelle-type drug delivery vehicle was made of PEG-b-poly(aspartic acid) (PEG-b-PAsp), immobilizing the hydro-phobic anticancer drugDXR [188-191]. After this achievement by Kataoka et al., a great amount of research on polymer micelles has been carried out, and there are several reviews available on the subject [192-194]. 

The spherical self-assembly in aqueous solution originates from the mushroom shape of the molecule. Moreover, when hydrophobic molecules are present, the micelle includes them as guest molecules, acting as a molecular capsule. As selective adsorption of Pcs to cancer cells has been used as a tool for PDT, these micelles hold potential as drug delivery systems. 

In addition to lipid-like molecules, polymers can also form self-assembling particulates [8]. As expected, the amphiphilic polymers do form polymeric micelles with polar part orienting towards the surface of the particle and the hydrophobic part orienting towards the core of the particle. Also, in this case, different complicated self-assembled structures can be tailored by using block copolymers with regular blocks of monomer units but, only the simpler ones have been investigated so far in the context of drug delivery. 

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