Selenium disulfide

Selenium disulfide Mellor, 1941, Vol. 3, 377 A mixture may ignite under impact. 

Selenium-containing donors, synthesis and manufacture of, 22 212 Selenium dichloride, 22 75t Selenium diethyldithiocarbamate, 22 73t Selenium dioxide, 22 73t, 75t, 88 toxicify of, 22 95 Selenium disulfide, 22 73t Selenium hexafluoride, 22 75t, 87 toxicify of, 22 96 Selenium hypofluorite, 22 75t Selenium iodides, 22 87 Selenium monobromide, 22 75t, 88 Selenium monochloride, 22 75t, 87 in selenium recovery, 22 85 Selenium monoxide, 22 88 Selenium oxidation, selenium recovery via, 22 81-83... 

Compounds Selenium dioxide selenium trioxide selenium oxychloride sodium selenite sodium selenate hydrogen selenide selenic acid selenium sulfide selenium disulfide... 

Commercial selenium disulfide SeSj has been found to be very untoxic (for mice LD 50 per os 3.7 g/kg). Thus the material is 100 times less toxic than selenites. Daily oral administration of 5, 25, or 125 mg/kg of SeS2 for seven and a half weeks was tolerated by mice without signs of intoxication. As SeSj is used as a constituent of shampoos several investigations on the effects of the sulfide on the eyes, skin, and hair have been published chemotherapeutic activity... 

Selenium disulfide, SeS2, may be made by the reaction of selenious acid, H2Se03, and hydrogen sulfide. Its manufacture is described by B.W. Nordlander in US Patents 1,860,154 and 1,860,336. It is prepared in a detergent suspension for therapeutic use. 

SELENIUM(I 0 DISULFIDE (1 2) see SBROOO SELENIUM DISULFIDE (2.5%) SHAMPOO see SBR500 SELENIUM(I30 DISULnDE SHAMPOO (2.5%) see SBR500... 

The toxicity depends on the molecular form. More soluble compounds, for example, sodium selenite, are more toxic than the less soluble elemental selenium, selenium sulfide, or selenium disulfide. Selenium dioxide is highly to moderately toxic, with oral... 

LD50 values in rodents from 20 to 70 mg kg The dermal LD50 for selenium dioxide in rabbits is 4 mg kg. Oral LD50 values for sodium selenite range from 14 to 7 mg kg whereas an LD50 of 138mg kg was noted for selenium disulfide, and an LD50 of > 6 g kg was noted for elemental selenium. 

Selenium sulfide (i.e., selenium monosulfide) and selenium disulfide are less water soluble and are of lower acute toxicity than sodium selenate or sodium selenite. There are no reported human deaths due to ingestion of selenium sulfide. The LD50 value for the gavage administration of 1-20% selenium disulfide... 

The LD50 and lethal LOAEL values from each reliable study following oral exposure to elemental selenium dust, selenium dioxide dissolved in water (selenious acid), sodium selenate, sodium selenite, potassium selenate, and dietary selenium for each species and exposure duration are recorded in Table 3-2 and plotted in Figure 3-2. The LOAEL values for death in rats and mice following acute and intermediate oral exposures to selenium sulfide or selenium disulfide are recorded in Table 3-3 and plotted in Figure 3-3. 

No studies were located regarding hematological effects in humans or other animals after oral exposure to selenium sulfide or selenium disulfide. 

A mixture of selenium sulfide and selenium disulfide administered to mice daily by gavage for 13 weeks at a dose of 464 mg selenium sulfides/kg/day produced an increase in the incidence and severity of interstitial nephritis compared with the controls, whereas a daily dose of 216 mg selenium sulfides/kg did not elicit renal toxicity (NTP 1980c). In rats, selenium sulfide by oral intubation at 31.6 mg selenium sulfides/kg/day for 13 weeks did not produce renal effects (NTP 1980c). 

Occupational studies indicate that humans absorb elemental selenium dusts and other selenium compounds, but quantitative inhalation toxicokinetic studies in humans have not been done. Studies in dogs and rats indicate that following inhalation exposure, the rate and extent of absorption vary with the chemical form of selenium. Studies in humans and experimental animals indicate that, when ingested, several selenium compounds including selenite, selenate, and selenomethionine are readily absorbed, often to greater than 80% of the administered dose. Although a study of humans did not detect evidence of dermal absorption of selenomethionine, one study of mice indicates selenomethionine can be absorbed dermally. There is little or no information available on the absorption of selenium sulfides, but selenium disulfides are not believed to be absorbed through intact skin. 

Dermal absorption was tested in eight women at a maximum dose of 0.0029 mg selenium/kg as selenomethionine (0.05% L-selenomethionine in a lotion). No detectable increase in serum selenium concentrations was observed but because the concentrations tested were so low, absorption cannot be ruled out (Burke et al. 1992a). Absorption of selenium disulfide was examined using a monthly 24-hour urine specimen in 16 persons who washed their hair weekly with a 1% selenium disulfide shampoo. No differences were found from control urinary selenium levels over the 1-year exposure period (Cummins and Kimura 1971). No absorption of selenium from selenium sulfide was seen in 15 persons who applied a 2.5% selenium sulfide suspension to their torsos and allowed it to remain on the body overnight (Kalivas 1993). 

Massachusetts Oil and hazardous material Selenious acid Selenium and compounds Selenium dioxide Selenium disulfide Selenium oxide Selenium oxychloride Selenium sulfide Selenourea BNA 2001... 

Selenium diethyldithiocarbamate Selenium monosulfide (SeS) Selenium disulfide (SeS2) Selenium dioxide (Se02)... 

Several other factors relevant to differences in sebum composition on the scalp have been described in the literature. Anionic surfactants or ether extraction of the scalp does not stimulate the rate of refatting [147] selenium disulfide in a shampoo increases sebum production [148,149] and alters the ratio of triglycerides to free fatty acids found in sebum. Presumably, this latter effect involves reducing the microflora responsible for lipolytic enzymes on the scalp that hydrolyze triglycerides to free fatty acids. Zinc pyrithione appears to behave similarly and has been shown to increase hair greasiness... 

Regulatory BP, EP compliance Manuf./Distrib. Spectrum Quality Prods. http //WWW.spectrumchemical. com Voi gt Global Distrib. http //www.vgdllc.com See also Selenium disulfide... 

Selenium sulfide. See Selenium disulfide Selenium tetrafluoride CAS 13465-66-2... 

Maidenhair fern (Adiantum capillus-veneris) extract Onion (Allium cepa) extract Pine (Pinus palustris) tar Piroctone olamine Potassium undecylenoyl hydrolyzed collagen Quaternium-51 Sage (Salvia officinalis) extract Selenium disulfide Sulfur TEA-undecenoyl hydrolyzed collagen Undecylenamide DEA Undecyleneth-6 Yarrow (Achillea millefolium) oil antidandruff agent, hair treatments Quaternium-51... 

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