Selenium monosulfide

There are two interesting paradoxes concerning selenium. The first is that excess selenium is toxic however, at lower levels it is a protective agent against the toxicity of cadmium, methylmercury, arsenic, copper, and thalium. The second paradox involves carcinogenicity. The US National Cancer Institute found selenium monosulfide (administered orally) to be carcinogenic in rodents however, many epidemiological studies associate selenium intake with lower cancer rates in humans. Moreover, in... 

Selenium sulfide (i.e., selenium monosulfide) and selenium disulfide are less water soluble and are of lower acute toxicity than sodium selenate or sodium selenite. There are no reported human deaths due to ingestion of selenium sulfide. The LD50 value for the gavage administration of 1-20% selenium disulfide... 

Henschler and Kirschner (1969) reported an LD50 of 3,700 mg selenium sulfide/kg for mice administered by gavage in aqueous 0.5% carboxymethylcellulose. Administration of single gavage doses of selenium monosulfide to rats produced death in 3/15 animals dosed with 50 mg/kg, 3/6 animals dosed with 75 mg/kg, 1/2 animals dosed with 100 mg/kg, and 2/2 animals dosed with 125 mg/kg (Moore et al. 

The genotoxicity of selenium monosulfide was assessed in an in vivo/in vitro micronucleus and chromosome aberration assay in rats (Moore et al. 1996b). Male Wistar rats (4/dose) were administered 25, 50, or 100 mg/kg selenium monosulfide in corn oil. Negative control rats received corn oil by gavage and positive controls were injected intraperitoneally with 20 mg/kg cyclophosphamide. Animals were sacrificed 24 hours after treatment and the femur marrow and spleen were removed and cultured. Spleen and marrow cultures were examined 24 or 48 hours after establishment, respectively. No increase in chromosome aberrations or micronucleus formation in cells from treated rats was observed. 

Synonyms Selenium monosulfide selenium sulfide [SeS] selensulfid (German) sulfur selenide (Sse) Selenium disulphide selenium sulfideb sulfur selenide... 

Selenium diethyldithiocarbamate Selenium monosulfide (SeS) Selenium disulfide (SeS2) Selenium dioxide (Se02)... 

Selenium monosulfide. See Selenium sulfide Selenium oxide. See Selenium dioxide Selenium sulfide CAS 7446-34-6... 

Synonyms Selenium monosulfide Selsun sulfide Sulfur selenide... 

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