Selectivity pharmacological

Southan, G. J., Szabo, C.. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms, Biochem. Pharmacol. 51 (1996),... 

Servan-Schreiber D, Perlstein WM, Cohen JD, Mintun M. (1998). Selective pharmacological activation of limbic structures in human volunteers a positron emission tomography study. J Neuropsychiatry Clin Neurosci. 10(2) 148-59. 

The existence of distinct cholino- ses allows selective pharmacological ceptors at different cholinergic synap- interventions. 

P. Compain, O. R. Martin, C. Boucheron, G. Godin, L. Yu, K. Ikeda, and N. Asano, Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher disease, Chembiochem, 7 (2006) 1356-1359. 

Abecarnil, a P-carboline-3-carboxylic-ester, has a selective pharmacological profile in animal studies and is under development for the treatment of generalized anxiety disorder. It has anxiolytic and anticonvulsant activity, with a low abuse liability and low dependence potential (Stephens et al. 1993). Although the initial results of phase 11 clinical trials were promising (Ballenger et al. 1991), they have not been yet confirmed in phase 111 clinical trials. 

Although originally developed as selective pharmacological agents, SSRls... 

Select Pharmacological Properties of Drugs Most Often Used in Treating Tuberculosis... 

Peptide Mimics and Oligonucleotide Medicines The middle section of Table 5.4 shows new types of pharmaceuticals not classified as biopharmaceuticals, although they may have a selective pharmacological action similar to... 

Figure 9.1 Proposed rank ordering of methods informing species selection for safety assessment of biopharmaceuticals. Various methods used for selecting pharmacologically relevant species for toxicological studies of biopharmaceuticals are presented, ordered (top to bottom) by the extent to which the data might impact the decision on which species to use. In cases where the methods are further discussed in this chapter, the relevant figure/table numbers are provided. These types of analyses may also be used for creating data packages for small molecules, although not typically for species selection.

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