Selectivity of Pharmacological Response in Lead Assessment

COMPARING SELECTIVITY OF PHARMACOLOGICAL RESPONSE IN LEAD ASSESSMENT 

In one of these studies, an effort was made to understand the observed dislipidemia and insulin resistance associated with long-term HIV protease inhibitor therapy [25]. Five HIV protease inhibitors (lopinavir, nelfinavir, 

Vitamin E RRR- a-tocopherol all-rac- a-tocopherol HepG2 dose response No difference in EC50 or IC50 [17] 

Estrogen, xenoestrogens 17p-estradiol MCF7 Highly similar responses among [34] 

HIV protease inhibitors atazanavir, HepG2 Divergence in class, dislipidemia [25] 

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