Selectin-ligand interactions in lymphocyte function

Lymphocytes constitute a population of leukocytes centrally important to the specificity of immune responses they are the only cells in a rnarnmahan organism capable of distinguishing different antigenic determinants. To fulfill its function, the immune system continuously establishes and maintains diverse populations of mature lymphocytes and provides them with the capability to respond to foreign antigen at a variety of effector sites. -  

Potential Roles of Seleetin-Ligand Interactions in Cancer 

Some of the carbohydrate determinants functioning as selectin ligand glycans have been identified as tumor-associated antigens. In the early 1970s, evidence had been well established that profound changes in surface caibohydrate 

IV Syntheses of Oligosaccharides and Derivatives Corresponding to the Sialyl-Lewis (sLe ) and Sialyl-Lewis (sLe ) Determinants 

By the early 1970s, the art of oligosaccharide synthesis had reached a remarkable level, so that chemical syntheses of practical amounts of various blood-group-related ohgosaccharides became feasible, including the Lewis determinants. In the context of the present article, a brief overview will be given of seminal contributions by the schools of Lemieux. Paulsen, Ogawa,2 8,269 Schmidt, 

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