Selectin-ligand interactions

The precise chemical nature of some of the ligands involved in selectin-ligand interactions has been determined. All three selectins bind sialylated and fucosy-lated oligosaccharides, and in particular all three bind sialyl-Lewis (Figure 47-12), a structure present on both glycoproteins and glycolipids. Whether this compound is the actual ligand involved in vivo is not estab-... 

Tsujishita, H, Hiramatsu, Y, Kondo, N, Ohmoto, H, Kondo, H, Kiso, M, Hasegawa, A, Selectin-ligand interactions revealed by molecular dynamics simulation in solution, J. Med. Chem., 40, 362-369, 1997. 

Inhibition of the selectin-ligand interactions is an attractive strategy for treating inflammation-related diseases [173,174,175]. As such, sLe has been intensively used as lead structure for development of anti-inflammatory drugs both in industry and academia [176,177,178]. 

Potential Roles of Selectin-Ligand Interactions in Cancer. 263... 

Inhibition of Selectin Ligand Interactions Alternatives to Small Molecules. 406... 

Static binding results for physiological binding under shear stress, flow chamber assays are also mentioned. Some representative animal models used to study the inhibition of selectin-ligand interactions in vivo are listed in Section VII. 

Selectin-ligand interactions of E- or P-selectin were not enhanced following mild periodate oxidation of the ligands. However, subsequent treatment of rolling cells with cyanoborohydride caused arrest of the cells. Attachment of the cells was not reversed by treatment with EDTA, indicating the formation of covalent bonds. As indicated by Puri and Springer, the phenomena observed are difficult to explain on the basis of Schiff base formation alone.5 ... 

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