Selected Developments in Micro-analytical Technology

As the ability to generate more samples per imit time increases with improvements in the capabilities of combinatorial and microreactor systems, there is a growing need for a faster analytical response. To keep the Development Cycle (react, analyze, handle data, and design next experiment) functioning at a productive rate there is need to characterize samples and convert the corresponding analyhcal data into valuable information. This information will then feed the Design of Experiment part of the cycle. Significant effort has been put into approaches to speed up the ability to analyze samples and this has often been aided by miniaturization of the analytical equipment. 

Micro Instrumentation for High Throughput Experimentation and Process Intensification - a Tool for PAT Edited by M. V. Koch, K. M. VandenBussche and R. W. Chrisman Copyright 2007 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31425-6 

It is envisioned that many of these technologies will ultimately be compatible with the NeSSI (New Sampling and Sensor Initiative) platform and, thus, will be added to the growing toolbox of characterization technologies that could be used in an array format for the generahon of meaningful data. The technologies described include  

Application of On-line Raman Spectroscopy to Characterize and Optimize a Continuous Microreactor 

5-8 years. However, little information is found in the literature describing the application of analytical sensors or instrumentation to microreactors to improve reaction optimization or control. The present chapter demonstrates the use of Raman spectroscopy as a tool for analyzing and understanding a chemical reaction performed in a continuous microreactor. 

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Selected Developments in Micro-analytical Technology Column Preparation and Stationary Phases... 

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