Stimulation test secretin

Secretin stimulation test. Secretin-cholecystoldnin (CCK) test... 

Secretin stimulates the secretion of pancreatic juice and bicarbonate, but stumilation of the secretion of pancreatic enzymes is inconsistent. Addition of CCK (or a synthetic equivalent) to the secretin stimulation test provides a stimulus to the secretion of pancreatic enzymes, allowing a more complete assessment of pancreatic reserve than can be obtained with secretin alone. The functional activity of CCK resides in the C-terminal octapeptide sequence (CCK-8), and either this octapeptide or ceruletide (a synthetic decapeptide identical to the natural decapeptide cerulein) can be used to stimulate pancreatic enzyme secretion (Figure 48-7). 

See also Lundh test, secretin-cholecystokinin-pancreozymin stimulation test, secretin stimulation test... 

A periodic measurement of stool fat excretion by means of the method of Van de Kamec [97] or using the less unpleasant near-infrared analysis [98-100] allows quantitative evaluation of the degree of steatorrhea. Besides this, several function tests where the pancreas is directly stimulated by an infusion of secretin and/or cholecystokinin (reviewed in Ref. 101) or indirect tests requiring the administration of an exogenous pancreas enzyme substrate as V-benzoyl-L-tyrosyl-p-aminobenzoic acid (NBT-PABA) or fluorescein dilaurate (pancreo-lauryl test) (Fig. 12) are available. The NBT-PABA test measures intraluminal... 

Secretin is a GI function test, which increases the volume and bicarbonate content of secreted pancreatic juices. It is indicated in stimulation of pancreatic secretions, including bicarbonate, to aid in diagnosis of pancreatic exocrine dysfunction stimulation of gastrin secretion to aid in diagnosis of... 

It can be used in conjunction with secretin to measure the capacity of the pancreas to secrete enzymes. In this test secretin is used in combination, as this stimulates the production of bicarbonate in pancreatic fluid. The secretin-... 

An in vivo test for the assessment of pancreatic function which consists of giving secretin (which stimulates pancreatic bicarbonate production) and cholecystokinin-pancreozymin (which stimulates the secretion of pancreatic enzymes). Pancreatic fluid is collected and analysed for bicarbonate and one of the pancreatic enzymes (trypsin, amylase or lipase). Low outputs occur in pancreatic disease. 

Trypsin can also be measured in duodenal juice after pancreatic stimulation by secretin-pancreozymin or by a test meal, e.g. as in the Lundh test (q.v.). A deficient output of trypsin is suggestive of pancreatic disease. 

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