Cholecystokinin-pancreozymin

The hormone pancreozymin (cholecystokinin-pancreoz3miin) stimulates the protein secretory cycle in the exocrine pancreas (Harper Raper, 1943) it also elicits phosphatidylinositol breakdown, formation of phosphatidic acid, and increased turnover of the polar headgroups of these phosphatides. These effects are essentially the same as those observed in response to acetylcholine (Hokin, M.R.,... 

Cholecystokinin, CCK or pancreozymin (gallbladder, pancreas), many forms exist CCK 58 58 ... 

Cholecystokinin (= Pancreozymin)] (4kDa protein) Animals brain GI tract CCK-R agonist ianorexigenic, nociception, T pancreatic exocrine secretion, J- gastric emptying]... 

C-terminal octapeptide SQ 19844 Kinevac. C H N -OjjS mol wt [143.29. C 51.48%, H 5.47%, N 12.25%, O 22.39%, S 8.41%. The C-terminal octapeptide of choleeys-tokinin-pancreozymin (see cholecystokinin). Structurally similar to caerulein, q.v., it evokes a variety of biological responses similar to CCK-PZ, includiug smooth-muscle contraction of the gall bladder and small intestine, relaxation of the choledochoduodenal junction, protein secretion by the pancreas and acid secretion by the stomach. It is more active than cholecystokinin on a weight or molar basis. Initial isoln V. Mutt, J. E. Jorpes, Eur. J. Biochem. 6, 156 (1968). Prepn M. A. Ondetti et al. Get. pat. 1,922,185 corresp to U.S. pat, 3,723,406 (1969, 1970, both to Squibb) eidem, J. Am. Chem. Soc. 92, 195 (1970), Mechanical and metabolic effects K. E. Andersson ef al., Acta Physiol... 

Cholecystokinin, pancreozymin a tissue hormone consisting of 33 amino acids (porcine), Jlf, 3,838. It is formed in the mucosa of the upper intestine in response to the presence of chyme (add mixture of partially digested food) or to a nervous stimulus, and promotes contraction of the gall bladder and secretion of pancreatic juice. [F.Ctecelebi L.J. Miller J. Biol. Chem. 270 (1995) 3435-3441]... 

The conclusion that a peptide such as bradykinin consisting of nine amino acids does not have a preferred conformation but that a well defined geometry develops from a certain chain length on (secretin contains twenty-seven amino acids, glucagon with fairly similar sequence and somewhat similar spectra twenty-nine amino acids), would be attractive but is not well founded. Examination of the ORD and CD spectra of the intestinal hormone cholecystokinin-pancreozymin (CCK), a single chain peptide of 33 amino acids, gives no evidence for structural rigidity which would express itself in spectra similar to those of helical molecules. 

At one time there were thought to be two separate hormones, cholecystokinin which produced contraction of the gall bladder and pancreozymin which increased the secretion of pancreatic enzymes. However it is now known that a single hormone secreted by the upper small intestine performs both activities. 

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