Sclerosing agents

EBL is the recommended form of endoscopic therapy for acute variceal bleeding, although endoscopic injection sclerotherapy (injection of 1 to 4 mL of a sclerosing agent into the lumen of the varices) may be used if the ligation is technically difficult. EBL is often used for upper GI tract hemorrhage secondary to portal hypertension and varices. 

Salaman MH, Glendenning OM. 1957. Tumor promotion in mouse skin by sclerosing agents. BrJ Cancer 11 434-444. 

It is a sclerosing agent for bleeding oesophageal varices, varicose veins, bleeding gastroduodenal ulcers etc. 

Quinine has certain minor pharmacological actions quite distinct from its antimalarial role analgesic (in prohibitively high dosage), striated muscle relaxant, and antipyretic. Other uses of quinine are as a sclerosing agent, a bowel evacuant, and in dermatological practice. 

Sclerosing agents. Chemicals may be used to cause inflammation and thrombosis in veins so as to induce permanent obliteration, e.g. ethanolamine oleate injection, sodium tetradecyl sulphate (given i.v. for varicose veins) and oily phenol injection (given submucously for haemorrhoids). Local reactions, tissue necrosis and embolus can occur. 

Allergic contact dermatitis, characterized by erythema, palpable edema, and raised borders, was attributed to benzyl alcohol (2). In this case, the benzyl alcohol was present as a preservative in an injectable solution of sodium tetradecyl sulfate, a sclerosing agent used for the treatment of varicose veins. The author provided a hst of 151 injectable formulations (48 for subcutaneous administration) that contained benzyl alcohol as a preservative in the range 0.5-2.0%. The list included hormones and steroids, antihypertensive drugs (reserpine), vitamin formulations (vitamins B12 and Bg), ammonium sulfate, antihistamines, antibiotics, heparin (17 brands), tranquillizers, and sclerosing agents (sodium morrhuate and sodium tetradecyl sulfate). 

When bleomycin is used as a sclerosing agent in adults, a dose of up to 1 mg/kg is generally instilled into the chest through a thoracostomy tube. Bleomycin 60 mg intrapleu-rally caused a fever over 39°C in two of 21 patients with malignant pleural effusions it settled without treatment and was not associated with local discomfort (15). 

In sclerotherapy an irritant is introduced into varicose veins and esophageal varices, causing a local inflammatory reaction and obliteration of the veins concerned. Sclerosing agents include lauromacrogol 400, mono-ethanolamine oleate, sodium morrhuate, and sodium tetradecylsulfate. 

Lauromacrogol 400 is a solvent and non-ionic emulsifier. In medicaments it is used as topical anesthetic, an antipruritic, and a sclerosing agent (1). 

Monoethanolamine is also used to produce a variety of salts with therapeutic uses. For example, a salt of monoethanolamine with vitamin C is used for intramuscular injection, while the salicylate and undecenoate monoethanolamine salts are utilized respectively in the treatment of rheumatism and as an antifungal agent. However, the most common therapeutic use of monoethanolamine is in the production of ethanolamine oleate injection, which is used as a sclerosing agent. ... 

Morrhuate sodium is a sclerosing agent that causes venous intima inflammation and thrombus formation, which occludes the injected vein and subsequently forms fibrous tissue that results in partial or complete vein obliteration. It is indicated for obliteration of primary varicosed veins consisting of simple dilation with competent valves. 

Sodium salt. Devaricin. White powder. Sol in water. therap Cat Sclerosing agent. 

THERAP CAT Sclerosing agent antimalarial local anesthetic. 

THERap CAT Has been used in contraceptive jellies. The sodium salt has been used as sclerosing agent. 

This drug is a sclerosing agent. It causes irritation to the vascular wall, causing an inflammatory response and vasoconstriction. This results in hemostasis. 

Salaman, M.H. and O.M. Glendenning Tumour promotion in mouse skin by sclerosing agents Brit. J. Cancer 11 (1957)434-444. 

Indications Bacterial, antiprotozoal, rickettsial and fungal infections sclerosing agent for pleural or pericardial effusion, adjunct therapy for H. pylori and other Gl infections, Lyme disease Common drug examples ... 

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